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Recombinant Human IL-1 beta/IL-1F2 GMP Protein

Recombinant Human IL-1 beta/IL-1F2 GMP Protein

Animal Free11

≥97%(SDS-PAGE&SEC-HPLC)

功能和特点

表达系统: E. coli
Accession #: P01584
蛋白标签: No tag
生物活性: Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED50 for this effect is <12 pg/mL. The specific activity of recombinant human IL-1 beta is >5.0 x 10^7 IU/mg, which is calibrated against the human IL-1 beta WHO International
内毒素水平: <0.01 EU/μg

有货

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
rp168388-GMP-100μg	100μg	期货
rp168388-GMP-1mg	1mg	期货

查看相关系列

Accession#:P01584 (6) Gene ID:3553 (7) IL-1 beta (4) IL-1F2 (2) IL1B (8)

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基本描述

产品名称	Recombinant Human IL-1 beta/IL-1F2 GMP Protein
规格或纯度	ActiBioPure™, 生物活性, GMP, 无载体, 无动物源, High performance, ≥97%(SDS-PAGE&SEC-HPLC)
生化机理	Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. Acts as a sensor of S.pyogenes infection in skin: cleaved and activated by pyogenes SpeB protease, leading to an inflammatory response that prevents bacterial growth during invasive skin infection. Post-translational: Activation of the IL1B precursor involves a CASP1-catalyzed proteolytic cleavage. Processing and secretion are temporarily associated.
生物活性	Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED50 for this effect is <12 pg/mL. The specific activity of recombinant human IL-1 beta is >5.0 x 10^7 IU/mg, which is calibrated against the human IL-1 beta WHO International
内毒素水平	<0.01 EU/μg
表达系统	E. coli
氨基酸	117-269 aa
蛋白标签	No tag
N-末端序列	Ala-Pro-Val-Arg-Ser-Leu-Asn-(Cys)-Thr-Leu & Pro-Val-Arg-Ser-Leu-Asn-(Cys)-Thr-Leu-Arg
无载体	Yes
无动物源	Yes
Accession #	P01584
来源	Recombinant
预测分子量	17 kDa
SDS-PAGE	17 kDa under reducing conditions.

产品规格参数

储存缓冲液	Lyophilized from a 0.2 μm filtered solution in PBS.
复溶	Reconstitute at 100-200 μg/mL in PBS.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	A minimum of 12 months when stored at ≤ -20 ℃ as supplied. 1 month, 2 to 8 ℃ under sterile conditions after reconstitution. 3 months, ≤ -20 ℃ under sterile conditions after reconstitution. Upon delivery aliquot. Avoid freeze/thaw cycle.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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Recombinant Human IL-1 beta/IL-1F2 GMP Protein

库存信息

库存信息

基本描述

AI解读

产品规格参数

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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溶液计算器

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