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Recombinant Human IL-17F Protein

功能和特点
  • 表达系统: E.coli
  • Accession #: Q96PD4
  • 蛋白标签: No tag
  • 生物活性: Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 20 ng/ml, corresponding to a specific activity of > 5.0 × 104 IU/mg.
  • 内毒素水平: <1 EU/µg
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货号 (SKU) 包装规格 是否现货 价格 数量
rp147435-10μg
10μg 现货 Stock Image
rp147435-50μg
50μg 现货 Stock Image
rp147435-100μg
100μg 现货 Stock Image
rp147435-1mg
1mg 期货 Stock Image

基本描述

产品名称 Recombinant Human IL-17F Protein
别名 重组人白介素17F蛋白
英文别名 Cytokine ML-1 | IL17F | IL-17F | IL-17Finterleukin-17F | interleukin 17F | ML1 | ML-1 | IL17A | CANDF6 | Cytokine ML-1 | IL-17F
规格或纯度 ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, High performance, ≥95%(SDS-PAGE)
产品介绍


Purity
>95% by SDS-PAGE and HPLC analyses.

Function
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation.

生物活性 Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 20 ng/ml, corresponding to a specific activity of > 5.0 × 104 IU/mg.
内毒素水平 <1 EU/µg
表达系统 E.coli
种属 Human
氨基酸 31-163 aa
纯度 >95%(SDS-PAGE, HPLC)
蛋白标签 No tag
蛋白长度 Full length protein
无载体 Yes
无动物源 Yes
Accession # Q96PD4
来源 Recombinant
预测分子量 30.1 kDa
SDS-PAGE 16.4 kDa, under reducing conditions.

AI解读

图片

Recombinant Human IL-17F Protein (rp147435)-Protein Bioactivity
Fully biologically active when compared to standard. The ED₅₀ as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 20 ng/mL, corresponding to a specific activity of > 5.0 × 10⁴ IU/mg.


Recombinant Human IL-17F Protein (rp147435)-SDS-PAGE
Recombinant Human IL-17F Protein was resolved with SDS-PAGE under reducing (R) and visualized by Coomassie® Blue staining. Showing a single band at 16.4 kDa.

产品规格参数

应用 Cell Culture,Active
物理外观 Lyophilized
复溶 We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 6 mM HCl to a concentration of 0.1mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度 -20°C储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconst

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找到3个结果

批号(Lot Number) 证书类型 日期 货号
ZJ23F0600463 分析证书 24-03-26 rp147435
ZJ23F0600464 分析证书 24-03-26 rp147435
ZJ23F0600465 分析证书 24-03-26 rp147435

此产品的引用文献

1. Wright JF, Bennett F, Li B, Brooks J, Luxenberg DP, Whitters MJ, Tomkinson KN, Fitz LJ, Wolfman NM, Collins M et al..  (2008)  The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex..  J Immunol,  181  (4): (2799-805).  [PMID:18684971] [10.1021/op500134e]

参考文献

1. Wright JF, Bennett F, Li B, Brooks J, Luxenberg DP, Whitters MJ, Tomkinson KN, Fitz LJ, Wolfman NM, Collins M et al..  (2008)  The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex..  J Immunol,  181  (4): (2799-805).  [PMID:18684971] [10.1021/op500134e]

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