Recombinant Mouse Prolactin Protein

Animal Free11

Carrier Free

≥98%(SDS-PAGE&HPLC)

功能和特点

表达系统: E.coli
Accession #: P06879
蛋白标签: No tag
生物活性: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using rat Nb2-11 cells is less than 1.0 ng/ml, corresponding to a specific activity of > 1.0 × 10^6 IU/mg.
内毒素水平: ＜0.1 EU/μg

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货号 (SKU)	包装规格	是否现货
rp154542-10μg	10μg	现货
rp154542-50μg	50μg	现货
rp154542-100μg	100μg	现货
rp154542-1mg	1mg	期货

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点击查看蛋白信息: PRL

Accession#:P06879 (1) Gene ID:19109 (1) PRL (6) Prolactin (5)

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基本描述

产品名称	Recombinant Mouse Prolactin Protein
别名	重组小鼠Prolactin蛋白 \| 重组小鼠催乳素蛋白 \| AV290867 \| Lactogenic Hormone \| Luteotropic Hormone \| Mammotropin \| OTTMUSP00000000651 \| PRL \| Prl1a1 \| Prol \| Prolactin precursor \| RATPRLSD1 \| RNPROL \| RP23-351I6.2 \| RP3-404K8.1 \| Decidual prolactin \| GHA1 \| Growth hormone A1 \| Prolactin
规格或纯度	ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, High performance, ≥98%(SDS-PAGE&HPLC)
产品介绍	Purity > 98% by SDS-PAGE and HPLC analyses. Relevance Various hormones are secreted from the anterior pituitary during development and growth. Prolactin is a growth factor secreted by the anterior pituitary that is necessary for the proliferation and differentiation of the mammary glands. Prolactin acts primarily on the mammary gland by promoting lactation. Background: Prolactin (gene name PRL) is a secreted neuroendocrine pituitary hormone that acts primarily on the mammary gland to promote lactation, but has pleiotropic effects in both males and females (1-3). Mouse Prolactin is predominantly found as 23 kDa non-glycosylated monomers. Mouse prolactin shares 60% and 85% amino acid sequence identity with human and rat prolactin, respectively; however, activation of the human prolactin receptor by rat prolactin has been demonstrated (3). Prolactin is synthesized mainly by the anterior pituitary in all mammals, where secretion is under tonic inhibition by hypothalamic dopamine (2, 3). Secretion can be stimulated by suckling and diurnally by estradiol in rodents during pro-estrus and mating (2). In humans prolactin is also produced peripherally, while in rodents, the only known non-pituitary source is the placenta (1-3). Mouse serum Prolactin declines until mid-pregnancy, but increases in late pregnancy (1). Post-translational modifications such as polymerization, phosphorylation, and proteolytic cleavage can alter the activities of prolactin (3). Cleavage by matrix metalloproteinases or Cathepsin D can produce N-terminal 16 kDa antiangiogenic fragments also called vasoinhibins (4, 5). Thrombin can produce C-terminal 16 kDa fragments that are not antiangiogenic (3). The prolactin receptor (gene name PRLR) is a transmembrane type I glycoprotein that belongs to the cytokine hematopoietic receptor family. Expression of the prolactin receptor is widespread (2, 3). Each prolactin molecule is thought to bind two receptor molecules (6).
生物活性	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using rat Nb2-11 cells is less than 1.0 ng/ml, corresponding to a specific activity of > 1.0 × 10^6 IU/mg.
内毒素水平	＜0.1 EU/μg
表达系统	E.coli
种属	Mouse
氨基酸	30-226 aa
纯度	＞98%(SDS-PAGE and HPLC)
蛋白标签	No tag
蛋白长度	Full length protein
无载体	Yes
无动物源	Yes
Accession #	P06879
来源	Recombinant
预测分子量	22.4 kDa
SDS-PAGE	22.4 kDa

图片

SDS-PAGE: Recombinant Mouse Prolactin Protein (rp154542)

Recombinant Mouse Prolactin Protein (rp154542)-SDS-PAGE
Recombinant Mouse Prolactin Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining. Showing a single band at 22.4 kDa under reducing conditions and 20.0 kDa under non-reducing conditions.

Protein Bioactivity: Recombinant Mouse Prolactin Protein (rp154542)

Recombinant Mouse Prolactin Protein (rp154542)-Protein Bioactivity
Fully biologically active when compared to standard. The ED₅₀ as determined by a cell proliferation assay using rat Nb2-11 cells is less than 1.0 ng/mL, corresponding to a specific activity of > 1.0 × 10⁶ IU/mg.

产品规格参数

应用	Cell Culture,Active,SDS-PAGE
物理外观	Lyophilized
储存缓冲液	Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconst

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找到3个结果

批号(Lot Number)	证书类型	日期	货号
ZJ23F0600332	分析证书	24-03-26	rp154542
ZJ23F0600333	分析证书	24-03-26	rp154542
ZJ23F0600334	分析证书	24-03-26	rp154542

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Recombinant Mouse Prolactin Protein

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