Recombinant Rat Prolactin Protein

Animal Free11

Carrier Free

生物活性级

ActiBioPure™

High performance

≥98%(SDS-PAGE)

功能和特点

表达系统: E.coli
Accession #: P01237
蛋白标签: No tag
生物活性: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using rat Nb2-11 cells is less than 1.0 ng/ml, corresponding to a specific activity of > 1.0 × 10⁶ IU/mg.
内毒素水平: < 1 EU/μg

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货号 (SKU)	包装规格	是否现货
rp155196-10μg	10μg	现货
rp155196-50μg	50μg	现货
rp155196-100μg	100μg	现货
rp155196-1mg	1mg	期货

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点击查看蛋白信息: PRL

Accession#:P01237 (1) Gene ID:24683 (1) PRL (6) Prolactin (5)

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基本描述

产品名称	Recombinant Rat Prolactin Protein
别名	Decidual prolactin; GHA1; Growth hormone A1; Lactogenic hormone; Luteotropic hormone; Mammotropin; PRL; Prolactin; Prolactin precursor; 重组大鼠催乳素(PRL); 重组大鼠Prolactin/PRL蛋白
规格或纯度	无动物源, Carrier Free, 生物活性, ActiBioPure™, High performance, ≥98%(SDS-PAGE)
产品介绍	Various hormones are secreted from the anterior pituitary during development and growth. Prolactin is a growth factor secreted by the anterior pituitary that is necessary for the proliferation and differentiation of the mammary glands. Background The neuroendocrine pituitary hormone Prolactin (PRL), also known as lactotrophin, mamotrophin, luteotropic hormone (LTH), or luteotropin, is a secreted hormone that affects reproduction and homeostasis in vertebrates. The functions of PRL can be placed in six broad categories: 1) reproduction and lactation; 2) growth and development; 3) endocrinology and metabolism; 4) brain and behavior; 5) immunomodulation; and 6) electrolyte balance. PRL is secreted by the anterior pituitary gland, mammary gland, placenta, brain, uterus, decidua, dermal fibroblasts, B cells, T cells, NK cells, and some breast cancer cell lines. Although the major form of PRL is a 23 kDa monomeric protein, splice variants of 14, 16, and 22 kDa have been identified. PRL has also been found to be glycosylated, phosphorylated, dimerized, and polymerized. Glycosylation, phosphorylation, dimerization, or polymerization of PRL result in lower activity. Cell activation by PRL is mediated by a single chain membrane-bound protein belonging to the class 1 cytokine superfamily. The PRL receptor (PRL R) contains an extracellular, transmembrane, and intracellular domain. Transcriptional regulation of the PRL R gene results in several different species-dependent isoforms of PRL R being produced. Although the cytoplasmic domains of the different isoforms vary in length and composition, their extracellular domains are identical. In rats, three major PRL receptor isoforms have been described, a short (291 amino acid), an intermediate (393 amino acid), and a long (591 amino acid). PRL receptors are found in mammary tissue, pituitary gland, brain, heart, lung thymus, spleen, liver, pancreas, kidney, adrenal gland, uterus, skeletal muscle, and skin. A soluble form of PRL-R containing the 206NH2-terminal amino acids of the extracellular domain is secreted by mammary epithelial cells and is found in milk. Binding of the transmembrane PRL R results in ligand dimerization followed by binding and phosphorylation of Jak2. Jak2 then phosphorylates STAT and the long form of PRL R. C-src, fyn, and the Ras/Raf/MAP kinase pathway have also been found to be activated upon PRL R ligand binding.
生物活性	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using rat Nb2-11 cells is less than 1.0 ng/ml, corresponding to a specific activity of > 1.0 × 10⁶ IU/mg.
内毒素水平	< 1 EU/μg
表达系统	E.coli
种属	Rat
氨基酸	30-226 aa
纯度	＞98%(SDS-PAGE)
蛋白标签	No tag
蛋白长度	Full length protein
无载体	Yes
无动物源	Yes
Accession #	P01237
来源	Recombinant
预测分子量	22.6 kDa
SDS-PAGE	22.6 kDa

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Protein Bioactivity: Recombinant Rat Prolactin Protein (rp155196)

Recombinant Rat Prolactin Protein (rp155196)-Protein Bioactivity
Fully biologically active when compared to standard. The ED₅₀ as determined by a cell proliferation assay using rat Nb2-11 cells is less than 1.0 ng/mL, corresponding to a specific activity of > 1.0 × 10⁶ IU/mg.

SDS-PAGE: Recombinant Rat Prolactin Protein (rp155196)

Recombinant Rat Prolactin Protein (rp155196)-SDS-PAGE
Recombinant Rat Prolactin Protein was resolved with SDS-PAGE under reducing (R) and visualized by Coomassie® Blue staining. Showing a single band at 22.6 kDa.

产品规格参数

物理外观	Lyophilized
储存缓冲液	Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4
复溶	It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Lyophilized protein should be stored at -20°C for 1 year. Upon reconstitution, store at 2°C to 8°C for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g. 0.1% BSA, 10%FBS, 5%HSA or 5% trehalose solution), protein ali

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找到3个结果

批号(Lot Number)	证书类型	日期	货号
ZJ23F0600454	分析证书	24-03-26	rp155196
ZJ23F0600455	分析证书	24-03-26	rp155196
ZJ23F0600456	分析证书	24-03-26	rp155196

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Recombinant Rat Prolactin Protein

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