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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| rp156671-10μg (试用装) 申请此免费试用装（?） 作为尊贵的客户，您每年可免费申请一次试用装产品，尽享探索与享受！
|
10μg |
现货  |
| |
| rp156671-50μg |
50μg |
期货 |
| |
| rp156671-100μg |
100μg |
期货 |
| |
| rp156671-1mg |
1mg |
期货 |
|
| 产品名称 | Recombinant Human S100B Protein |
|---|---|
| 别名 | 重组人S100B蛋白 | 重组人S100 beta蛋白 |
| 英文别名 | beta (neural) | NEF | S100 beta | S100 calcium binding protein B | S100 calcium-binding protein B | S100 calcium-binding protein, beta (neural) | S-100 calcium-binding protein, beta chain, 10protein S100-B | S-100 protein beta chain | S-100 protein subuni |
| 规格或纯度 | ActiBioPure™, Bioactive, Carrier Free, Azide Free, ≥95%(SDS-PAGE) |
| 产品介绍 |
Purity:>95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： 100B, previously called S100 beta, belongs to the S100 family within the EF-hand superfamily of Ca2+ binding proteins. S100 proteins contain two EF-hand motifs that differ in affinity, separated by a hinge region with a hydrophobic cleft that is exposed upon Ca2+ binding. S100B is a 91 amino acid (aa) protein, after removal of the initial methionine, and is found as homodimers of 10.4 kDa monomers. Human S100B shares 99%, 98%, 100%, 99% and 97% aa sequence identity with mouse, rat, rabbit, equine and bovine S100B, respectively. Within the S100 family, human S100B shows the highest aa identity (59%) with S100A1. S100B is expressed primarily by astrocytes and oligodendrocytes in the central nervous system, and by Schwann cells in the peripheral nervous system. Ca2+-bound S100B interacts in vitro with at least 20 cytoplasmic proteins, including several structural molecules such as tubulin and GFAP. It can inhibit the phosphorylation of these kinase substrates and others such as tau and neuromodulin. Astrocytes can secrete S100B, which then acts in a cytokine-like manner. Nanomolar concentrations of S100B are secreted constitutively, promote proliferation, and are neurotrophic and anti-apoptotic. Blood levels of S100B reflect extracellular concentrations within the nervous system, and are elevated in Down’s syndrome, Alzheimer’s disease and Tourette’s syndrome, metabolic stress, acute brain injury and brain tumors. Micromolar concentrations of S100B can be destructive and pro-apoptotic; they induce the expression of iNOS, COX-2, IL-1, IL‑6 and TNF-alpha by microglia, astrocytes or neurons. Most extracellular actions of S100B can be mediated by RAGE (receptor for advanced glycation end products), which is also a receptor for other S100 proteins. |
| 生物活性 | Testing in progress |
| 表达系统 | E. coli |
| 氨基酸 | 1-92 aa |
| 纯度 | >95%(SDS-PAGE) |
| 蛋白标签 | N-His |
| 无载体 | Yes |
| 无动物源 | No |
| Accession # | P04271 |
| 来源 | Recombinant |
| 预测分子量 | 11.7 kDa |
| SDS-PAGE | 10.6 kDa, reducing conditions; 10.6 kDa, non-reducing conditions |
Recombinant Human S100B protein (rp156671) - SDS-PAGE
Recombinant Human S100B protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 10.6 kDa.
| 物理外观 | Lyophilized |
|---|---|
| 储存缓冲液 | Lyophilized from 10mM PBS, pH7.8 |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions. |
| 储存温度 | -20°C储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | Store at -20°C for 1 year. Avoid freeze/thaw cycle. |
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
 ZJ23F1101765 |
分析证书 | 23-12-01 | rp156671 |
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