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Recombinant Human CD40 Ligand/TNFSF5 Protein

Recombinant Human CD40 Ligand/TNFSF5 Protein

功能和特点

规格或纯度: Carrier Free, >98% SDS-PAGE, E.coli, His tag, 108-261 aa
蛋白标签: N-His tag

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货号 (SKU)	包装规格	是否现货
rp169583-10μg	10μg	期货
rp169583-50μg	50μg	期货
rp169583-100μg	100μg	期货
rp169583-1mg	1mg	期货

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基本描述

产品名称	Recombinant Human CD40 Ligand/TNFSF5 Protein
别名	CD154 antigen; CD154; CD40 antigen ligand; CD40 Ligand; CD40L; CD40-L; CD40LG; CD40LIGM; gp39; hCD40L; HIGM1; T-B cell-activating molecule; T-BAM; T-cell antigen Gp39; TNF-related activation protein; TNFSF5; TNFSF5IMD3; TRAP; TRAPtumor necrosis factor (li
英文别名	CD154 antigen; CD154; CD40 antigen ligand; CD40 Ligand; CD40L; CD40-L; CD40LG; CD40LIGM; gp39; hCD40L; HIGM1; T-B cell-activating molecule; T-BAM; T-cell antigen Gp39; TNF-related activation protein; TNFSF5; TNFSF5IMD3; TRAP; TRAPtumor necrosis factor (li
规格或纯度	Carrier Free, >98% SDS-PAGE, E.coli, His tag, 108-261 aa
产品介绍	Purity:>98%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： CD40 Ligand, also known as TNFSF, CD154, TRAP, and gp39, is a 34-39 kDa type II transmembrane glycoprotein that belongs to the TNF superfamily. Mature human CD40 Ligand consists of a 22 amino acid (aa) cytoplasmic domain, a transmembrane segment, and an 215 aa extracellular region. The extracellular domain of human CD40 Ligand shares 74% and 76% aa sequence identity with mouse and rat CD40 Ligand, respectively. Similar to other TNF superfamily members, CD40 Ligand forms a bioactive homotrimer, both as membrane bound and soluble forms. The 18 kDa soluble form (aa 113-261) arises from proteolytic processing. Mutation and alternative splicing generate additional forms of CD40 Ligand that are often truncated or non-trimerizable. CD40 Ligand is expressed on platelets, as well as on activated T cells and B cells, basophils, eosinophils, fibroblasts, mast cells, monocytes, natural killer cells, vascular endothelial cells, and smooth muscle cells. CD40 Ligand binds to CD40, which is expressed on the surface of B cells, dendritic cells, macrophages, monocytes, platelets, endothelial, and epithelial cells. The interaction of CD40 Ligand with CD40 initiates signaling in both CD40 and CD40 Ligand expressing cells. CD40 ligation by CD40 Ligand promotes B cell activation and T cell-dependent humoral responses. CD40 Ligand dysregulation on T cells and antigen presenting cells contributes to the immune deficiency associated with HIV infection and AIDS. It is also implicated in the pathology of multiple cardiovascular diseases including atherosclerosis, atherothrombosis, and restenosis.
表达系统	E.coli
氨基酸	108-261 aa
序列	MHHHHHHENSFEMQKGDQNPQIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSNREASSQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVNVTDPSQVSHGTGFTSFGLLKL
蛋白标签	N-His tag
无载体	Yes
无动物源	No
预测分子量	17.7 kDa
SDS-PAGE	16.0 kDa, reducing conditions; 16.0 kDa, non-reducing conditions

产品规格参数

物理外观	Lyophilized
储存缓冲液	Lyophilized from 10mM PB, 500mM NaCl,10% Glycerol
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at -20°C stable up to 1 year. Avoid freeze / thaw cycle.

图片

SDS-PAGE: Recombinant Human CD40 Ligand/TNFSF5 Protein (rp169583)

Recombinant Human CD40 Ligand/TNFSF5 Protein (rp169583) - SDS-PAGE
Recombinant Human CD40 Ligand/TNFSF5 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 16.0 kDa.

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Recombinant Human CD40 Ligand/TNFSF5 Protein

库存信息

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基本描述

产品规格参数

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