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Recombinant Human CD40 Ligand/TNFSF5 Protein

功能和特点
  • 表达系统: E. coli
  • Accession #: P29965
  • 蛋白标签: N-His
  • 生物活性: Testing in progress
  • 内毒素水平: <1 EU/μg
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货号 (SKU) 包装规格 是否现货 价格 数量
rp169583-10μg (试用装)
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10μg 现货 Stock Image
rp169583-50μg
50μg 现货 Stock Image
rp169583-100μg
100μg 现货 Stock Image
rp169583-1mg
1mg 现货 Stock Image

基本描述

产品名称 Recombinant Human CD40 Ligand/TNFSF5 Protein
别名 重组人CD40 Ligand/TNFSF5蛋白
英文别名 CD154 antigen | CD154 | CD40 antigen ligand | CD40 Ligand | CD40L | CD40-L | CD40LG | CD40LIGM | gp39 | hCD40L | HIGM1 | T-B cell-activating molecule | T-BAM | T-cell antigen Gp39 | TNF-related activation protein | TNFSF5 | TNFSF5IMD3 | TRAP | TRAPtumor n
规格或纯度 ActiBioPure™, Bioactive, Carrier Free, Azide Free, ≥98%(SDS-PAGE)
产品介绍


Purity:>98%, by SDS-PAGE visualized with Coomassie® Blue Staining.
Description:
CD40 Ligand, also known as TNFSF, CD154, TRAP, and gp39, is a 34-39 kDa type II transmembrane glycoprotein that belongs to the TNF superfamily. Mature human CD40 Ligand consists of a 22 amino acid (aa) cytoplasmic domain, a transmembrane segment, and an 215 aa extracellular region. The extracellular domain of human CD40 Ligand shares 74% and 76% aa sequence identity with mouse and rat CD40 Ligand, respectively. Similar to other TNF superfamily members, CD40 Ligand forms a bioactive homotrimer, both as membrane bound and soluble forms. The 18 kDa soluble form (aa 113-261) arises from proteolytic processing. Mutation and alternative splicing generate additional forms of CD40 Ligand that are often truncated or non-trimerizable. CD40 Ligand is expressed on platelets, as well as on activated T cells and B cells, basophils, eosinophils, fibroblasts, mast cells, monocytes, natural killer cells, vascular endothelial cells, and smooth muscle cells. CD40 Ligand binds to CD40, which is expressed on the surface of B cells, dendritic cells, macrophages, monocytes, platelets, endothelial, and epithelial cells. The interaction of CD40 Ligand with CD40 initiates signaling in both CD40 and CD40 Ligand expressing cells. CD40 ligation by CD40 Ligand promotes B cell activation and T cell-dependent humoral responses. CD40 Ligand dysregulation on T cells and antigen presenting cells contributes to the immune deficiency associated with HIV infection and AIDS. It is also implicated in the pathology of multiple cardiovascular diseases including atherosclerosis, atherothrombosis, and restenosis.

生物活性 Testing in progress
内毒素水平 <1 EU/μg
表达系统 E. coli
氨基酸 108-261 aa
纯度 >98% SDS-PAGE
蛋白标签 N-His
无载体 Yes
无动物源 No
Accession # P29965
来源 Recombinant
预测分子量 17.7 kDa
SDS-PAGE 16.0 kDa, reducing conditions; 16.0 kDa, non-reducing conditions

AI解读

图片

Recombinant Human CD40 Ligand/TNFSF5 Protein (rp169583) - SDS-PAGE
Recombinant Human CD40 Ligand/TNFSF5 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 16.0 kDa.

产品规格参数

物理外观 Transparent gelatinous
储存缓冲液 Lyophilized from 10mM PB, 500mM NaCl,10% Glycerol
复溶 We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度 -20°C储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 Store at -20°C stable up to 1 year. Avoid freeze / thaw cycle.

技术规格说明书

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找到6个结果

批号(Lot Number) 证书类型 日期 货号
ZJ23F1201885 分析证书 24-09-29 rp169583
ZJ23F1201884 分析证书 23-12-13 rp169583
ZJ23F1201883 分析证书 23-12-13 rp169583
ZJ23F1201882 分析证书 23-12-13 rp169583
ZJ23F1201881 分析证书 23-12-13 rp169583
ZJ23R1100168 分析证书 23-11-24 rp169583

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