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货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
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A126525-20mg |
20mg |
现货 ![]() |
| |
A126525-50mg |
50mg |
现货 ![]() |
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A126525-250mg |
250mg |
现货 ![]() |
| |
A126525-1g |
1g |
现货 ![]() |
|
别名 | 酪氨酸激酶抑制剂AG 490 |
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英文别名 | AG 490;Tyrphostin AG 490;AG490; tyrphostin ag 490;ag 490; (E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide;2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide; 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide |
规格或纯度 | ≥98% |
英文名称 | AG-490 (Tyrphostin B42) |
生化机理 | AG-490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Inhibitor of JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways and potently inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo.JAK2/3 inhibitor (IC 50 values are ~10 and 25 μM, respectively). Inhibits downstream activation of STAT5a/b. Effects synaptic plasticity and cytokine-independent cell growth in vitro and spatial learning, memory and tumor cell invasion in vivo . |
应用 | Tyrphostin AG has been used to block IL-6 cytokine signaling to study its effects on glial cell reactivity. AG 490 has also been used as a JAK2 inhibitor in human umbilical vein endothelial cells |
储存温度 | -20°C储存 |
运输条件 | 超低温冰袋运输 |
备注 | 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。有毒,请参阅SDS以获取更多信息。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
产品介绍 |
AG-490 (Tyrphostin AG 490)是EGFR抑制剂,IC50为100nM,比对ErbB2的抑制性高135倍,对Lck,Lyn,Btk,Syk和Src无活性。Tyrphostin AG has been used to block IL-6 cytokine signaling to study its effects on glial cell reactivity. AG 490 has also been used as a JAK2 inhibitor in human umbilical vein endothelial cells AG-490 (Tyrphostin AG 490) is an inhibitor of EGFR with IC50 of 0.1 μM, 135-fold more selective for EGFR versus ErbB2, also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src. |
PubChem SID | 488195367 |
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IUPAC Name | (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide |
INCHI | InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+ |
InChi Key | TUCIOBMMDDOEMM-RIYZIHGNSA-N |
Canonical SMILES | C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N |
WGK Germany | 3 |
PubChem CID | 5328779 |
分子量 | 294.3 |
PubChem CID | 5328779 |
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CAS Registry No. | 133550-30-8 |
ChEMBL Ligand | CHEMBL56543 |
PubChem SID | 488195367 |
溶解性 | DMSO ≥57mg/mL Water <1.2mg/mL Ethanol ≥8mg/mL |
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敏感性 | 对光敏感、对空气敏感、对热敏感 |
熔点 | 215°C |
象形图 |
![]() Toxic ![]() Environmental Hazard |
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信号词 | Danger |
危险声明 |
H301: Toxic if swallowed H400: Very toxic to aquatic life |
预防措施声明 | P273,P321,P405,P501,P264,P270,P391,P330,P301+P316 |
WGK Germany | 3 |
输入批号以搜索COA:
1. Gazit A, Osherov N, Posner I, Yaish P, Poradosu E, Gilon C, Levitzki A. (1991) Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.. J Med Chem, 34 (6): (1896-907). [PMID:1676428] |
2. Zeng Y et al.. (2014) Inhibition of STAT5a by Naa10p contributes to decreased breast cancer metastasis.. Carcinogenesis, 35 (10): (2244-53). [PMID:24925029] |
3. Wang Y & Li Y. (2018) MiR-29c inhibits HCV replication via activation of type I IFN response by targeting STAT3 in JFH-1-infected Huh7 cells.. RSC Adv, 8 (15): (8164-8172). [PMID:35542013] |
4. Zhang Z et al.. (2021) Neuritin inhibits astrogliosis to ameliorate diabetic cognitive dysfunction.. J Mol Endocrinol, 66 (4): (259-272). [PMID:33729996] |
5. Li HN et al.. (2021) Red nucleus IL-33 facilitates the early development of mononeuropathic pain in male rats by inducing TNF-a through activating ERK, p38 MAPK, and JAK2/STAT3.. J Neuroinflammation, 18 (): (150). [PMID:34225736] |
6. Guo YJ et al.. (2018) Red nucleus interleukin-1ß evokes tactile allodynia through activation of JAK/STAT3 and JNK signaling pathways.. J Neurosci Res, 96 (12): (1847-1861). [PMID:30216497] |