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CD25 Rat mAb

Rat monoclonal (PC-61.5.3) to CD25
规格或纯度: mAb(PC-61.5.3); Rat anti Mouse CD25 Antibody; Flow; Unconjugated
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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
A412017-1mg (试用装)
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A412017-5mg
5mg 现货 Stock Image

基本描述

别名 Anti-mouse CD25 (IL-2Rα)-InVivo; In Vivo MAb anti-mouse CD25 (IL-2Rα); CD25 Rat mAb; CD25, Il2r, Ly-43; Interleukin 2 receptor alpha chain antibody; CD25 antibody; CD25 antigen antibody; IDDM10 antibody; IL 2 receptor alpha subunit antibody; IL-2 recep
英文别名 Anti-mouse CD25 (IL-2Rα)-InVivo; In Vivo MAb anti-mouse CD25 (IL-2Rα); CD25 Rat mAb; CD25, Il2r, Ly-43; Interleukin 2 receptor alpha chain antibody; CD25 antibody; CD25 antigen antibody; IDDM10 antibody; IL 2 receptor alpha subunit antibody; IL-2 recept
规格或纯度 mAb(PC-61.5.3); Rat anti Mouse CD25 Antibody; Flow; Unconjugated
英文名称 CD25 Rat mAb
稳定性与储存 The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
应用 In vivo regulatory T cell depletion,Flow cytometry
来源 Hybridoma supernatant
储存温度 2-8°C储存,禁止冻结
运输条件 冰袋运输
产品介绍

应用:
体内调节性T细胞凋亡

流式细胞术
克隆号PC-61.5.3单克隆抗体能与小鼠IL-2Rα(也称为CD25、Ly-43、p55或Tac)反应。IL-2Rα是白细胞介素2受体α链的55 kDa配体结合亚单位。IL-2Rα在活化的成熟T淋巴细胞和B淋巴细胞、胸腺细胞亚群、前B细胞和T调节细胞上表达。IL-2Rα在淋巴细胞分化、活化和增殖中发挥作用。IL-2Rα以相对低的亲和力IL-2,然而,IL-2Rα与IL-2Rβ (CD122)和普通γ链(CD132)结合时,复合物以高亲和力结合IL-2。克隆号PC-61.5.3抗体已被证明可抑制IL-2与低亲和力和高亲和力IL-2Rα形式的结合。此外,克隆号PC-61.5.3抗体通常用于deplete体内CD4+FoxP3+ T调节细胞。

Application: In vivo regulatory T cell depletion; Flow cytometry

Recommended Isotype Control: In Vivo MAb rat IgG1 isotype control, anti-horseradish peroxidase

The PC-61.5.3 monoclonal antibody reacts with mouse IL-2Rα also known as CD25, Ly-43, p55, or Tac. IL-2Rα is the 55 kDa ligand-binding subunit of the interleukin 2 receptor alpha chain. IL-2Rα is expressed on activated mature T and B lymphocytes, thymocyte subsets, pre-B cells, and T regulatory cells. IL-2Rα has been shown to play roles in lymphocyte differentiation, activation, and proliferation. Alone, the IL-2Rα binds IL-2 with relatively low affinity however, when IL-2Rα associates with IL-2Rβ (CD122) and the common gamma chain (CD132) the complex binds IL-2 with high affinity. The PC-61.5.3 antibody has been shown to inhibit the binding of IL-2 to both the low and high affinity IL-2 receptor forms. Additionally, the PC-61.5.3 antibody is commonly used to deplete CD4+FoxP3+ T regulatory cells in vivo.

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FAQ
IgG抗体简介
IgG
流式细胞术
流式细胞仪分析

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