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货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
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C129279-100mg |
100mg |
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C129279-5g |
5g |
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C129279-10g |
10g |
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C129279-25g |
25g |
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C129279-100g |
100g |
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C129279-500g |
500g |
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别名 | 塞内昔布;4-[5-(4-甲苯基)-3-(三氟甲基)-1H-吡唑-1-基]甲磺酰胺;5-(4-甲苯基)-1-(4-磺酰基苯基)-3-(三氟甲基)吡唑 |
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英文别名 | 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide; CJ-016377; CP-598107; PF-00345549; Celebrex; Celebra PHA-00846533 SC-58635 YM-177;5-(4-Methylphenyl)-1-(4-sulfamoylphenyl)-3-(trifluoromethyl)pyrazole |
规格或纯度 | ≥99% |
英文名称 | Celecoxib |
生化机理 | Celecoxib is a selective cyclooxygenase-2 (Cox-2) inhibitor (IC50 = 40 nM) with low sensitivity against Cox-1. Celecoxib shows an anti-proliferative effect on nasopharyngeal carcinoma (NPC) cell lines including HNE1 (IC50 = 32.86 μM) and CNE1-LMP1 (IC50 = 61.31 μM).Selective COX-2 inhibitor (IC 50 values are 15 and 0.04 μM for COX-1 and COX-2 respectively). Non-steroidal anti-inflammatory drug. Enhances tumor cell apoptosis in vivo . Orally active. |
储存温度 | -20°C储存 |
运输条件 | 超低温冰袋运输 |
备注 | 100mg卖完停产,不再备货;如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
产品介绍 |
Celecoxib是环氧合酶-2(COX-2)选择性抑制剂,IC50为40 nM。A selective Cox-2 inhibitor Celecoxib is a selective COX-2 inhibitor with IC50 of 40 nM. |
EC号 | 685-962-5 |
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IUPAC Name | 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide |
INCHI | InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) |
InChi Key | RZEKVGVHFLEQIL-UHFFFAOYSA-N |
Canonical SMILES | CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F |
WGK Germany | 3 |
RTECS | DB2944937 |
关联CAS | 169590-42-5 |
PubChem CID | 2662 |
NSC Number | 719627 |
MeSH Entry Terms | 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide;Celebrex;celecoxib;SC 58635;SC-58635;SC58635 |
分子量 | 381.37 |
PubChem CID | 2662 |
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ChEMBL Ligand | CHEMBL118 |
Wikipedia | Celecoxib |
DrugBank Ligand | DB00482 |
ChEBI | CHEBI:41423 |
CAS Registry No. | 169590-42-5 |
RCSB PDB Ligand | CEL |
PEP | celecoxib |
Reactome Reaction | R-HSA-2309779 |
Reactome Drug | R-ALL-9677432 |
DrugCentral Ligand | 568 |
溶解性 | Soluble in DMSO (76 mg/ml at 25 °C), methanol, ethanol (33 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and dichloromethane., Soluble in DMSO (76 mg/ml at 25 °C), methanol, ethanol (33 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and dichloromethane |
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敏感性 | 对热、光线敏感 |
熔点 | 163 °C |
象形图 |
![]() Health Hazard |
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信号词 | Danger |
危险声明 |
H360: May damage fertility or the unborn child |
预防措施声明 | P280,P405,P501,P203,P318 |
WGK Germany | 3 |
RTECS | DB2944937 |
Merck Index | 1956 |
输入批号以搜索COA:
1. Penning TD, Talley JJ, Bertenshaw SR, Carter JS, Collins PW, Docter S, Graneto MJ, Lee LF, Malecha JW, Miyashiro JM et al.. (1997) Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).. J Med Chem, 40 (9): (1347-65). [PMID:9135032] |
2. Naji S et al.. (2019) Cadmium Induces Migration of Colon Cancer Cells: Roles of Reactive Oxygen Species, P38 and Cyclooxygenase-2.. Cell Physiol Biochem, 52 (6): (1517-1534). [PMID:31120230] |
3. Chen L et al.. (2017) L161982 alleviates collagen-induced arthritis in mice by increasing Treg cells and down-regulating Interleukin-17 and monocyte-chemoattractant protein-1 levels.. BMC Musculoskelet Disord, 18 (): (462). [PMID:29145862] |
4. Harati R et al.. (2020) Loss of miR-101-3p Promotes Transmigration of Metastatic Breast Cancer Cells through the Brain Endothelium by Inducing COX-2/MMP1 Signaling.. Pharmaceuticals (Basel), 13 (7): (). [PMID:32645833] |
5. Dey R & Bishayi B. (2020) TLR-2 neutralization potentiates microglial M1 to M2 switching by the combinatorial treatment of ciprofloxacin and dexamethasone during S. aureus infection.. J Neuroimmunol, 344 (): (577262). [PMID:32450430] |