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货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
---|---|---|---|---|
C412010-1mg |
1mg |
期货 ![]() |
| |
C412010-5mg |
5mg |
期货 ![]() |
| |
C412010-10mg |
10mg |
期货 ![]() |
|
产品名称 | Cemiplimab (anti-PD-1) |
---|---|
别名 | Libtayo; REGN-2810; cemiplimab-rwlc; 西米普利单抗; CD279 antigen; CD279; hPD-1; PD1; PD-1; PD1hPD-l; PDCD1; programmed cell death 1; programmed cell death protein 1; Protein PD-1; SLEB2; CD279 antibody; CD279 antigen antibody; hPD 1 antibody; hPD l antibody; hP |
英文别名 | Libtayo; REGN-2810; cemiplimab-rwlc; CD279 antigen; CD279; hPD-1; PD1; PD-1; PD1hPD-l; PDCD1; programmed cell death 1; programmed cell death protein 1; Protein PD-1; SLEB2; CD279 antibody; CD279 antigen antibody; hPD 1 antibody; hPD l antibody; hPD-1 anti |
规格或纯度 | Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated |
特异性 | PDCD1 |
应用 | ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt |
反应种属 | Human |
抗体类型 | Primary antibody |
---|---|
Format | Whole IgG |
亚型 | Human IgG4 |
轻链亚型 | Kappa |
SDS-PAGE | 26.0 kDa (Light Chain) & 49.9 kDa (Heavy Chain), under reducing conditions; 169.6 kDa, under non-reducing conditions. |
纯化方法 | Protein A purified |
来源 | CHO supernatant |
物理外观 | Liquid |
防腐剂 | No |
浓度 | Lot by Lot |
储存温度 | -80℃储存,避免反复冻融 |
运输条件 | 超低温冰袋运输 |
稳定性与储存 | Store at -80℃ for 18 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
CAS编号和信息 | 1801342-60-8 |
IMGT/mAb-DB | 846 |
---|---|
Reactome Reaction | R-HSA-9679421 |
Reactome Drug | R-ALL-9679434 |
输入批号以搜索COA:
1. Murphy AJ, Macdonald LE, Stevens S, Karow M, Dore AT, Pobursky K, Huang TT, Poueymirou WT, Esau L, Meola M et al.. (2014) Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice.. Proc Natl Acad Sci USA, 111 (14): (5153-8). [PMID:24706856] |
2. Falchook GS, Leidner R, Stankevich E, Piening B, Bifulco C, Lowy I, Fury MG. (2016) Responses of metastatic basal cell and cutaneous squamous cell carcinomas to anti-PD1 monoclonal antibody REGN2810.. J Immunother Cancer, 4 (13): (70). [PMID:27879972] |
3. Burova E, Hermann A, Waite J, Potocky T, Lai V, Hong S, Liu M, Allbritton O, Woodruff A, Wu Q et al.. (2017) Characterization of the Anti-PD-1 Antibody REGN2810 and Its Antitumor Activity in Human PD-1 Knock-In Mice.. Mol Cancer Ther, 16 (5): (861-870). [PMID:28265006] |
4. Migden MR, Rischin D, Schmults CD, Guminski A, Hauschild A, Lewis KD, Chung CH, Hernandez-Aya L, Lim AM, Chang ALS et al.. (2018) PD-1 Blockade with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma.. N Engl J Med, 379 (4): (341-351). [PMID:29863979] |