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货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
---|---|---|---|---|
D118757-1mg |
1mg |
现货 ![]() |
| |
D118757-5mg |
5mg |
现货 ![]() |
|
别名 | Amylin, DAP, IAPP |
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英文别名 | Amylin, DAP, IAPP, Insulinoma or Islet amyloid polypeptide |
规格或纯度 | ≥97% (HPLC) |
英文名称 | Diabetes Associated Peptide Amide human |
生化机理 | 胰岛淀粉样多肽(IAPP)是一种胰岛素的胰腺β-细胞表达的激素。 IAPP用来研究淀粉样蛋白沉积的作用机制以及对分子的错误折叠的过程的作用,特别是在II型糖尿病等条件下。内源性肽。强大的胰岛淀粉样多肽,降钙素(EC 50 = 0.67 nM),CGRP和肾上腺髓质素受体激动剂。有效抑制骨骼肌细胞中胰岛素刺激的葡萄糖摄取(IC 50 = 12 pM)。涉及II型糖尿病。 |
储存温度 | -20°C储存 |
运输条件 | 超低温冰袋运输 |
备注 | 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,这些产品最多可以使用一周。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
产品介绍 |
氨基酸序列 Lys-Cys-Asn-Thr-Ala-Thr-C?ys-Ala-Thr-Gln-Arg-Leu-Al?a-Asn-Phe-Leu-Val-His-Ser?-Ser-Asn-Asn-Phe-Gly-Ala-?Ile-Leu-Ser-Ser-Thr-Asn-V?al-Gly-Ser-Asn-Thr-Tyr-NH?2 Amino Acid Sequence Lys-Cys-Asn-Thr-Ala-Thr-C?ys-Ala-Thr-Gln-Arg-Leu-Al?a-Asn-Phe-Leu-Val-His-Ser?-Ser-Asn-Asn-Phe-Gly-Ala-?Ile-Leu-Ser-Ser-Thr-Asn-V?al-Gly-Ser-Asn-Thr-Tyr-NH?2 |
IUPAC Name | N-[1-[[1-[[1-[[4-amino-1-[[1-[[1-[[1-[[1-[[1-[[1-[[4-amino-1-[[4-amino-1-[[1-[[2-[[1-[[1-[[1-[[1-[[1-[[1-[[4-amino-1-[[1-[[2-[[1-[[4-amino-1-[[1-[[1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]-2-[[2-[2-[[16-(2-amino-2-oxoethyl)-19-(2,6-diaminohexanoylamino)-7,13-bis(1-hydroxyethyl)-10-methyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]propanoylamino]-3-hydroxybutanoyl]amino]pentanediamide |
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INCHI | InChI=1S/C165H261N51O55S2/c1-22-75(12)124(159(266)200-95(47-71(4)5)140(247)203-108(64-219)153(260)206-110(66-221)154(261)216-129(84(21)226)163(270)202-105(58-119(174)234)147(254)209-122(73(8)9)157(264)181-61-121(236)187-106(62-217)150(257)198-103(56-117(172)232)148(255)215-128(83(20)225)162(269)190-93(130(175)237)49-87-38-40-89(227)41-39-87)211-132(239)76(13)183-120(235)60-180-136(243)97(50-85-32-25-23-26-33-85)194-144(251)101(54-115(170)230)196-145(252)102(55-116(171)231)197-151(258)107(63-218)205-152(259)109(65-220)204-142(249)99(52-88-59-178-69-182-88)201-158(265)123(74(10)11)210-146(253)96(48-72(6)7)193-141(248)98(51-86-34-27-24-28-35-86)195-143(250)100(53-114(169)229)191-131(238)77(14)184-139(246)94(46-70(2)3)192-137(244)91(37-31-45-179-165(176)177)188-138(245)92(42-43-113(168)228)189-161(268)126(81(18)223)212-133(240)78(15)185-155(262)111-67-272-273-68-112(207-135(242)90(167)36-29-30-44-166)156(263)199-104(57-118(173)233)149(256)214-125(80(17)222)160(267)186-79(16)134(241)213-127(82(19)224)164(271)208-111/h23-28,32-35,38-41,59,69-84,90-112,122-129,217-227H,22,29-31,36-37,42-58,60-68,166-167H2,1-21H3,(H2,168,228)(H2,169,229)(H2,170,230)(H2,171,231)(H2,172,232)(H2,173,233)(H2,174,234)(H2,175,237)(H,178,182)(H,180,243)(H,181,264)(H,183,235)(H,184,246)(H,185,262)(H,186,267)(H,187,236)(H,188,245)(H,189,268)(H,190,269)(H,191,238)(H,192,244)(H,193,248)(H,194,251)(H,195,250)(H,196,252)(H,197,258)(H,198,257)(H,199,263)(H,200,266)(H,201,265)(H,202,270)(H,203,247)(H,204,249)(H,205,259)(H,206,260)(H,207,242)(H,208,271)(H,209,254)(H,210,253)(H,211,239)(H,212,240)(H,213,241)(H,214,256)(H,215,255)(H,216,261)(H4,176,177,179) |
InChi Key | PLOPBXQQPZYQFA-UHFFFAOYSA-N |
Canonical SMILES | CCC(C)C(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CC(=O)N)C(=O)NC(C(C)O)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(C)NC(=O)CNC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)N)NC(=O)C(CC(=O)N)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CC3=CN=CN3)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC(=O)N)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)N)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C5CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N5)C(C)O)C)C(C)O)CC(=O)N)NC(=O)C(CCCCN)N |
WGK Germany | 3 |
PubChem CID | 16158170 |
分子量 | 3903.28 |
UniProtKB | P10997 |
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CAS Registry No. | 122384-88-7 |
Ensembl Gene | ENSG00000121351 |
Entrez Gene | 3375 |
Wikipedia | Amylin |
GPCRdb Ligand | amylin |
WGK Germany | 3 |
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个人防护装备 | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
输入批号以搜索COA:
1. Majumder P et al.. (2021) A nexus of miR-1271, PAX4 and ALK/RYK influences the cytoskeletal architectures in Alzheimer's Disease and Type 2 Diabetes.. Biochem J, 478 (17): (3297-3317). [PMID:34409981] |
2. Majumder P et al.. (2019) Receptor tyrosine kinases (RTKs) consociate in regulatory clusters in Alzheimer's disease and type 2 diabetes.. Mol Cell Biochem, 459 (1-2): (171-182). [PMID:31154588] |
3. Suzuki H & Yamamoto T. (2014) Amylin-like immunoreactivity in pancreatic X cells of the black-spotted frog Rana (Pelophylax) nigromaculata.. Tissue Cell, 46 (6): (535-9). [PMID:25458814] |
4. Cooper GJ, Willis AC, Clark A, Turner RC, Sim RB, Reid KB. (1987) Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients.. Proc Natl Acad Sci USA, 84 (23): (8628-32). [PMID:3317417] |
5. Jaikaran ET, Clark A. (2001) Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology.. Biochim Biophys Acta, 1537 (3): (179-203). [PMID:11731221] |
6. Ravi Prakash Reddy Nanga,Jeffrey R Brender,Jiadi Xu,Gianluigi Veglia,Ayyalusamy Ramamoorthy. (2008-11-08) Structures of rat and human islet amyloid polypeptide IAPP(1-19) in micelles by NMR spectroscopy.. Biochemistry, 47 ((48)): (12689-12697). [PMID:18989932] |
7. Allam S Reddy,Lu Wang,Sadanand Singh,Yun L Ling,Lauren Buchanan,Martin T Zanni,James L Skinner,Juan J de Pablo. (2010-10-07) Stable and metastable states of human amylin in solution.. Biophysical journal, 99 ((7)): (2208-2216). [PMID:20923655] |
8. A Clark,M R Nilsson. (2004-01-15) Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes?. Diabetologia, 47 ((2)): (157-169). [PMID:14722650] |
9. Ravi Prakash Reddy Nanga,Jeffrey R Brender,Subramanian Vivekanandan,Ayyalusamy Ramamoorthy. (2011-07-05) Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment.. Biochimica et biophysica acta, 1808 ((10)): (2337-2342). [PMID:21723249] |