Dabigatran (BIBR 953),达比加群

规格或纯度: ≥98%

CAS编号: 211914-51-1
分子式: C₂₅H₂₅N₇O₃
分子量: 471.51
MDL号: MFCD09837830
PubChem编号: 216210

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货号 (SKU)	包装规格	是否现货
D126683-5mg	5mg	现货
D126683-25mg	25mg	现货
D126683-100mg	100mg	现货
D126683-500mg	500mg	期货

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coagulation factor II，thrombin Inhibitor

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基本描述

别名	达比加群
英文别名	BIBR 953;BIBR 953ZW;BIBR953;BIB-953;3-[[2-[[(4-carbamimidoylphenyl)amino]methyl]-1-methyl-benzoimidazole-5-carbonyl]-pyridin-2-yl-amino]propanoic acid
规格或纯度	≥98%
英文名称	Dabigatran (BIBR 953)
生化机理	Description: IC50 Value: 4.5nM (Ki); 10nM(Thrombin-induced platelet aggregation) [1] Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) undergoing advanced clinical development as its orally active prodrμg,dabigatran etexilate. in vitro: Dabigatran selectively and reversibly inhibited human thrombin(Ki: 4.5 nM) as well as thrombin-induced platelet aggregation (IC(50): 10 nM), while showing no inhibitory effect on other platelet-stimulating agents.Thrombin generation in platelet-poor plasma (PPP), measured as the endogenous thrombin potential (ETP) was inhibited concentration-dependently (IC(50): 0.56 microM). Dabigatran demonstrated concentration-dependent anticoagulant effects in various species in vitro, doubling the activated partial thromboplastin time (aPTT), prothrombin time (PT) and ecarin clotting time (ECT) in human PPP at concentrations of 0.23, 0.83 and 0.18 microM, respectively [1]. in vivo: Dabigatran prolonged th
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	Dabigatran (BIBR 953)是一种有效的非肽类凝血酶抑制剂，IC50为9.3 nM。A highly selective, reversible, and potent thrombin inhibitor Dabigatran (BIBR 953) is a potent nonpeptide thrombin inhibitor with an IC50 of 9.3 nM. A highly selective, reversible, and potent thrombin inhibitor

名称和标识符

IUPAC Name	3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoic acid
INCHI	InChI=1S/C25H25N7O3/c1-31-20-10-7-17(25(35)32(13-11-23(33)34)21-4-2-3-12-28-21)14-19(20)30-22(31)15-29-18-8-5-16(6-9-18)24(26)27/h2-10,12,14,29H,11,13,15H2,1H3,(H3,26,27)(H,33,34)
InChi Key	YBSJFWOBGCMAKL-UHFFFAOYSA-N
Canonical SMILES	CN1C2=C(C=C(C=C2)C(=O)N(CCC(=O)O)C3=CC=CC=N3)N=C1CNC4=CC=C(C=C4)C(=N)N
PubChem CID	216210
分子量	471.51

数据库链接

PubChem CID	216210
ChEMBL Ligand	CHEMBL48361
ChEBI	CHEBI:70752
Wikipedia	Dabigatran
CAS Registry No.	211914-51-1
RCSB PDB Ligand	4CC
Reactome Reaction	R-HSA-9015379
Reactome Drug	R-ALL-9015346

化学和物理性质

溶解性	DMSO <1mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL
敏感性	对空气敏感，对热敏感
熔点	270 °C(dec.)

安全和危险性（GHS）

象形图	Harmful
信号词	Warning
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation H302: Harmful if swallowed
预防措施声明	P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319

象形图

Harmful

信号词

Warning

危险声明

H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H302: Harmful if swallowed

预防措施声明

P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319

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Dabigatran (BIBR 953),达比加群

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基本描述

名称和标识符

数据库链接

化学和物理性质

安全和危险性（GHS）

质检证书(COA)

质检报告(COA)

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