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货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
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D127186-10mg |
10mg | 现货 | | |
D127186-50mg |
50mg | 现货 | | |
D127186-100mg |
100mg | 现货 | | |
D127186-250mg |
250mg | 现货 | | |
D127186-1g |
1g | 现货 | |
别名 | 达卡他韦 |
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英文别名 | BMS-790052; EBP 883; BMS 790052; N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]biscarbamic acid C,C'-dimethyl ester |
规格或纯度 | ≥98% |
英文名称 | Daclatasvir (BMS-790052) |
生化机理 | Daclatasvir (BMS-790052; EBP 883) is a first-in-class, highly-selective oral HCV NS5A inhibitor. NS5A is an essential component for hepatitis C virus (HCV) replication complex.Daclatasvir (BMS-790052; EBP 883)has broad genotype coverage and exhibits picomolar in vitro potency against genotypes 1a (EC50 50pm) and 1b (EC50 9pm).Daclatasvir (BMS-790052; EBP 883) produces a robust decline in HCV RNA (-3.6 logs after 48 hours from a single 100 mg) dosefollowing a single dose in patients chronically infected with HCV genotype 1.Daclatasvir a potent, direct acting, small\xa0 molecule inhbitor of HCV NS5A protein. It inhbibits replicons expressing a wide range of HCV genotypes with EC 50 values in the pM range (9 and 71 pM against the 1b and 2a genotypes, respectively). It also in |
储存温度 | -20°C储存 |
运输条件 | 超低温冰袋运输 |
产品介绍 |
Daclatasvir (BMS-790052)是一种高度选择性的HCV NS5A抑制剂,EC50为9-50 pM,在细胞培养中,作用于多种HCV复制基因型和JFH-1基因型2a的感染性病毒。 Daclatasvir (BMS-790052) is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM, for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a infectious virus in cell culture. |
PubChem SID | 488200771 |
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IUPAC Name | methyl N-[(2S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate |
INCHI | InChI=1S/C40H50N8O6/c1-23(2)33(45-39(51)53-5)37(49)47-19-7-9-31(47)35-41-21-29(43-35)27-15-11-25(12-16-27)26-13-17-28(18-14-26)30-22-42-36(44-30)32-10-8-20-48(32)38(50)34(24(3)4)46-40(52)54-6/h11-18,21-24,31-34H,7-10,19-20H2,1-6H3,(H,41,43)(H,42,44)(H,45,51)(H,46,52)/t31-,32-,33-,34-/m0/s1 |
InChi Key | FKRSSPOQAMALKA-CUPIEXAXSA-N |
Canonical SMILES | CC(C)C(C(=O)N1CCCC1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)C6CCCN6C(=O)C(C(C)C)NC(=O)OC)NC(=O)OC |
PubChem CID | 25154714 |
分子量 | 738.89 |
溶解性 | DMSO 148 mg/mL Water <1 mg/mL Ethanol 148 mg/mL |
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象形图 |
Health Hazard Harmful |
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信号词 | Warning |
危险声明 |
H319: Causes serious eye irritation H335: May cause respiratory irritation H373: Causes damage to organs through prolonged or repeated exposure H317: May cause an allergic skin reaction |
预防措施声明 | P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P260,P271,P304+P340,P403+P233,P272,P333+P313,P362+P364,P264+P265,P337+P317,P319 |
输入批号以搜索COA:
1. Gao M, Nettles RE, Belema M, Snyder LB, Nguyen VN, Fridell RA, Serrano-Wu MH, Langley DR, Sun JH, O'Boyle 2nd DR et al.. (2010) Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect.. Nature, 465 (7294): (96-100). [PMID:20410884] |