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盐酸白屈菜红碱

细胞渗透性蛋白激酶C抑制剂
规格或纯度: 98%
有货

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货号 (SKU) 包装规格 是否现货 价格 数量
D133831-5mg
 5mg 现货 Stock Image
D133831-10mg
 10mg 现货 Stock Image
D133831-25mg
 25mg 现货 Stock Image
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细胞信号转导和神经科学
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基本描述

别名 白屈菜赤碱
英文别名 1,2-Dimethoxy-N-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride;Toddalin chloride
规格或纯度 98%
英文名称 Chelerythrine chloride
生化机理 蛋白激酶C的细胞可渗透抑制剂（IC50 = 660 nM）; 关于磷酸盐受体具有竞争性，而关于ATP则非竞争性。具有广泛的生物活性，包括抗血小板，抗炎，抗菌和抗肿瘤作用。激活MAPK通路，独立于PKC抑制。抑制BclXL与Bak（IC50 =1.5μM）或Bad蛋白结合并刺激细胞凋亡。
储存温度 -20°C储存
运输条件 超低温冰袋运输
备注 25mg卖完停产，不再备货
产品介绍

Chelerythrine chloride Is an isoquinoline alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae. It has been reported to be a potent and selective inhibitor of PKC (protein kinase C, IC50=0.66 μM), and an independent activator of MAPK pathways. The compound has been observed to induce apoptosis in HL-60 human promyelocytic leukemia cells. The proposed method of action of apoptotic stimulation is throμgh the inhibition of binding BclXL to Bax or Bad at an IC50 = 1.5 μM. When used in combination with cisplatin inhibition of cell proliferation of non-small cell lung cancer cells was increased in an additive/synergistic pattern. Also throμgh inhibition of thromboxane formation and phosphoinositide breakdown chelerythrine chloride was demonstrated to inhibit rabbit platelet aggregation and release. Chelerythrine Chloride is an inhibitor of Cox-2.A potent and selective inhibitor of protein kinase C.

Chelerythrine chloride Is an isoquinoline alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae. It has been reported to be a potent and selective inhibitor of PKC (protein kinase C, IC50=0.66 μM), and an independent activator of MAPK pathways. The compound has been observed to induce apoptosis in HL-60 human promyelocytic leukemia cells. The proposed method of action of apoptotic stimulation is through the inhibition of binding BclXL to Bax or Bad at an IC50 = 1.5 μM. When used in combination with cisplatin inhibition of cell proliferation of non-small cell lung cancer cells was increased in an additive/synergistic pattern. Also through inhibition of thromboxane formation and phosphoinositide breakdown chelerythrine chloride was demonstrated to inhibit rabbit platelet aggregation and release. Chelerythrine Chloride is an inhibitor of Cox-2.
A potent and selective inhibitor of protein kinase C.

名称和标识符

EC号 223-444-9
IUPAC Name 1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride
INCHI InChI=1S/C21H18NO4.ClH/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22;/h4-10H,11H2,1-3H3;1H/q+1;/p-1
InChi Key WEEFNMFMNMASJY-UHFFFAOYSA-M
Canonical SMILES C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.[Cl-]
WGK Germany 3
RTECS FL9200000
PubChem CID 72311
分子量 383.82

化学和物理性质

溶解性 溶于water, 最高浓度 (mg/mL): 3.84, 最高浓度(mM): 10；溶于DMSO, 最高浓度 (mg/mL): 3.84, 最高浓度(mM): 10
熔点 195-205°C

安全和危险性（GHS）

象形图
ghs07

Harmful
信号词 Warning
危险声明 H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H302: Harmful if swallowed
H312: Harmful in contact with skin
H332: Harmful if inhaled
H302+H312+H332: Harmful if swallowed, in contact with skin or if inhaled
预防措施声明 P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P317,P337+P317,P332+P317,P319
WGK Germany 3
RTECS FL9200000

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