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货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
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D136754-50mg |
50mg |
现货 ![]() |
| |
D136754-100mg |
100mg |
现货 ![]() |
| |
D136754-250mg |
250mg |
现货 ![]() |
| |
D136754-1g |
1g |
现货 ![]() |
| |
D136754-5g |
5g |
现货 ![]() |
|
别名 | 二甲基草酰甘氨酸;N-(甲氧氧乙烯)-甘氨酸甲酯;N-[甲氧基(氧代)乙酰基]甘氨酸甲酯 |
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英文别名 | N-(Methoxyoxoacetyl)-glycine methyl ester; Dimethyloxallyl Glycine;N-[Methoxy(oxo)acetyl]glycine Methyl Ester;Dimethyloxaloylglycine |
规格或纯度 | ≥98% (HPLC) |
英文名称 | DMOG |
生化机理 | DMOG is a cell permeable prolyl-4-hydroxylase inhibitor, which upregulates HIF (hypoxia-inducible factor). The protein level of HIF-1α subunit is post-transcriptionally regulated by prolyl and asparaginyl hydroxylase (PAH). Suppression of PAH activity increases endogenous HIF-1α levels. DMOG is a cell permeable, competitive inhibitor of prolyl hydroxylase domain-containing proteins (PHDs and HIF-PHs). It has been discovered that the DMOG posseses neuroprotective effect on NFG deprived cell cultures throμgh preservation of glucose metabolism. DMOG also attenuates myocardial injury in a rabbit ischemia reperfusion model. DMOG is more potent than the older inhibitor 4-Phenyl-pyridine-2,5-dicarboxylic acid (R395889; Sigma-Aldrich rare chemicals library). The IC50 is 5.18 μM.Cell-permeable prolyl hydroxylase (PHD) inhibitor. Upregulates HIF activity. Active in vivo . |
储存温度 | -20°C储存 |
运输条件 | 超低温冰袋运输 |
备注 | 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。有关更多信息,请参阅SDS。有关溶解度,用法和处理的更多建议?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
产品介绍 |
Dimethyloxallyl Glycine(DMOG)是可渗透入细胞的HIF-1α脯氨酰羟化酶(HIF-PH)竞争性抑制剂。 用途 二甲基草酰甘氨酸(DMOG)用作TET3蛋白抑制剂。 DMOG用于: 缺氧诱导因子(HIF)活性测定 研究其对HIF-1α降解和肾脏再生的影响 脂肪组织DMOG预处理 CD34+细胞原代液体培养的媒介对照 刺激内皮细胞 Dimethyloxallyl Glycine(DMOG) is a cell permeable, competitive inhibitor of HIF-PH(HIF-1α prolyl hydroxylase). |
PubChem SID | 488190296 |
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溶解性 | Soluble in water at 30mg/ml. |
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沸点 | 182 °C/12 mmHg |
熔点 | 51 °C |
象形图 |
![]() Harmful |
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信号词 | Warning |
危险声明 |
H302: Harmful if swallowed |
预防措施声明 | P501,P264,P270,P330,P301+P317 |
WGK Germany | 3 |
输入批号以搜索COA:
1. Magdaleno C et al.. (2020) HIFa independent mechanisms in renal carcinoma cells modulate divergent outcomes in fibronectin assembly mediated by hypoxia and CoCl2.. Sci Rep, 10 (): (18560). [PMID:33122751] |
2. Cluff E et al.. (2022) Hypoxia-inducible factor-1 alpha expression is induced by IL-2 via the PI3K/mTOR pathway in hypoxic NK cells and supports effector functions in NKL cells and ex vivo expanded NK cells.. Cancer Immunol Immunother, (): (). [PMID:34999917] |