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货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
---|---|---|---|---|
D155733-1g |
1g | 现货 | | |
D155733-5g |
5g | 现货 | | |
D155733-25g |
25g | 现货 | | |
D155733-100g |
100g | 现货 | | |
D155733-500g |
500g | 现货 | |
别名 | 双氯芬酸;奥尔芬 |
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英文别名 | 2-(2,6-Dichloroanilino)phenylacetic Acid |
规格或纯度 | >98.0% |
英文名称 | Diclofenac |
储存温度 | 2-8°C储存 |
运输条件 | 冰袋运输 |
产品介绍 |
Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. Target: COX Diclofenac is a nonsteroidal anti-inflammatory drμg (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. The primary mechanism responsible for its anti-inflammatory, antipyretic, and analgesic action is thoμght to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin. Diclofenac (双氯芬酸) 是COX抑制剂,对绵羊的COX-1和-2的IC50分别为60和220 nM。 Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. Target: COX Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. The primary mechanism responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin. Diclofenac acid is a nonsteroidal anti-inflammatory compound and decycloxygenase (COX) inhibitor. |
IUPAC Name | 2-[2-(2,6-dichloroanilino)phenyl]acetic acid |
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INCHI | InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19) |
InChi Key | DCOPUUMXTXDBNB-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl |
RTECS | AG6310000 |
PubChem CID | 3033 |
分子量 | 296.15 |
Reaxy-Rn | 2146636 |
PubChem CID | 3033 |
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DrugBank Ligand | DB00586 |
CAS Registry No. | 15307-86-5 |
ChEBI | CHEBI:47381 |
ChEMBL Ligand | CHEMBL139 |
BindingDB Ligand | 13066 |
Wikipedia | Diclofenac |
BitterDB Ligand | 942 |
RCSB PDB Ligand | DIF |
PEP | diclofenac |
DrugCentral Ligand | 865 |
溶解性 | Chloroform (Slightly, Heated), Methanol (Slightly) |
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熔点 | 158°C |
象形图 |
Toxic Health Hazard Environmental Hazard |
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信号词 | Danger |
危险声明 |
H301: Toxic if swallowed H411: Toxic to aquatic life with long lasting effects H372: Causes damage to organs through prolonged or repeated exposure H361: Suspected of damaging fertility or the unborn child |
预防措施声明 | P273,P280,P264,P260,P201,P308+P313,P270,P391,P202,P301+P310+P330 |
RTECS | AG6310000 |
Reaxy-Rn | 2146636 |
Merck Index | 3081 |
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