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货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
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E126660-10mg |
10mg |
现货 ![]() |
| |
E126660-50mg |
50mg |
现货 ![]() |
| |
E126660-250mg |
250mg |
现货 ![]() |
| |
E126660-1g |
1g |
现货 ![]() |
| |
E126660-5g |
5g |
现货 ![]() |
|
别名 | MK-663;MK-0663;依托考昔;5-氯-6′-甲基-3-[4-(甲磺酰基)苯基]]-2,3′-联吡啶;5-氯-3-[4-(甲磺酰基)苯基]-2-(2-甲基-5-吡啶基)吡啶 |
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英文别名 | MK-663;MK-0663;Arcoxia;5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine; L-791456;Desvenlafaxine;;Tauxib;Nucoxia;Algix;Nucoxia;5-Chloro-3-[4-(methylsulfonyl)phenyl]-2-(2-methyl-5-pyridinyl)pyridine;5-Chloro-6′-methyl-3-[4-(methylsulfon |
规格或纯度 | ≥98.0% |
英文名称 | Etoricoxib |
生化机理 | Etoricoxib is a specific inhibitor of COX-2(Cyclooxygenase-2) |
储存温度 | 2-8°C储存,充氩 |
运输条件 | 冰袋运输 |
备注 | 10mg售完停产,不再备货 |
产品介绍 |
Etoricoxib(MK-0663)能选择性抑制COX-2,IC50为1.1_mu_M(LPS诱导的前列腺素E2合成实验),而对COX-1的IC50则为116_mu_M(凝血后血清血栓素B2生成实验)。A specific inhibitor of COX-2. EtoricoxibEtoricoxib(MK-0663) selectively inhibited COX-2 in human whole blood assays in vitro, with an IC50 value of1.1 ± 0.1 μM for COX-2 (LPS-induced prostaglandin E2 synthesis), compared with an IC50 value of 116 ± 8 μM for COX-1 (serum thromboxane B2 generation after clotting of the blood). |
IUPAC Name | 5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine |
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INCHI | InChI=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6-13)24(2,22)23/h3-11H,1-2H3 |
InChi Key | MNJVRJDLRVPLFE-UHFFFAOYSA-N |
Canonical SMILES | CC1=NC=C(C=C1)C2=C(C=C(C=N2)Cl)C3=CC=C(C=C3)S(=O)(=O)C |
WGK Germany | 3 |
PubChem CID | 123619 |
分子量 | 358.84 |
Beilstein号 | 8073797 |
PubChem CID | 123619 |
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Wikipedia | Etoricoxib |
ChEMBL Ligand | CHEMBL416146 |
DrugBank Ligand | DB01628 |
CAS Registry No. | 202409-33-4 |
ChEBI | CHEBI:6339 |
RCSB PDB Ligand | 5CH |
PEP | etoricoxib |
DrugCentral Ligand | 1113 |
溶解性 | Soluble in DMSO, and methanol |
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象形图 |
![]() Toxic |
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信号词 | Danger |
危险声明 |
H302: Harmful if swallowed H310: Fatal in contact with skin |
预防措施声明 | P280,P310,P302+P350 |
WGK Germany | 3 |
输入批号以搜索COA:
1. Wang R. (2021) Etoricoxib may inhibit cytokine storm to treat COVID-19.. Med Hypotheses, 150 (13): (110557). [PMID:33730601] |