氟灭酸

钙激活的氯离子通道阻滞剂；NSAID。同时激活TRPC6

规格或纯度: ≥99%

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货号 (SKU)	包装规格	是否现货
F129495-5g	5g	现货
F129495-25g	25g	现货
F129495-100g	100g	现货

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CaCC Channel blocker Cx23 Inhibitor Cx25 Inhibitor Cx26 Inhibitor Cx30 Inhibitor Cx30.2 Inhibitor Cx30.3 Inhibitor Cx31 Inhibitor Cx31.1 Inhibitor Cx31.9 Inhibitor Cx32 Inhibitor Cx36 Inhibitor Cx37 Inhibitor Cx40 Inhibitor Cx40.1 Inhibitor Cx43 Inhibitor Cx45 Inhibitor Cx46 Inhibitor Cx47 Inhibitor Cx50 Inhibitor Cx59 Inhibitor Cx62 Inhibitor KNa1.2 Activator Px1 Inhibitor Px2 Inhibitor Px3 Inhibitor TAS2R14 Agonist TRPA1 Activator TRPC5 Channel blocker TRPM2 Channel blocker TRPM4 Gating inhibitor TRPM5 Channel blocker TRPP2 Channel blocker

别名	2-(3-三氟甲基苯胺基)苯甲酸；2-[(3-三氟甲基苯基)氨基]苯甲酸；N-(3-三氟甲基苯基)邻氨基苯甲酸；氟芬那酸；N-(α,α,α-三氟-间甲苯基)邻氨基苯甲酸；
英文别名	2-[(3-Trifluoromethylphenyl)amino]benzoic Acid；N-(3-Trifluoromethylphenyl)anthranilic Acid；Flufenamic Acid；Nichisedan；Achless；Arlef；
规格或纯度	≥99%
英文名称	2-(3-Trifluoromethylanilino)benzoic Acid
生化机理	非甾体抗炎药（NSAID）。抑制钙激活的氯离子通道（CaCC）。也增加通过TRPC6通道的电流，并抑制通过TRPC3和TRPC7通道的电流。
储存温度	避光,室温
运输条件	常规运输
产品介绍	Application: An NSAID found to be a reversible gap junction blocker

PubChem SID	488179762
IUPAC Name	2-[3-(trifluoromethyl)anilino]benzoic acid
INCHI	InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20)
InChi Key	LPEPZBJOKDYZAD-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C(=C1)C(=O)O)NC2=CC=CC(=C2)C(F)(F)F
RTECS	CB4375000
PubChem CID	3371
分子量	281.23
Beilstein号	14(3)905
Reaxy-Rn	1996069

溶解性	溶于DMSO, 最高浓度 (mg/mL): 28.12, 最高浓度(mM): 100；溶于ethanol, 最高浓度 (mg/mL): 28.12, 最高浓度(mM): 100
敏感性	对光敏感
熔点	133.0 to 137.0 °C

象形图	Toxic Environmental Hazard Harmful
信号词	Danger
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation H301: Toxic if swallowed H411: Toxic to aquatic life with long lasting effects
预防措施声明	P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P391,P330,P264+P265,P301+P316,P337+P317,P332+P317,P319
RTECS	CB4375000
Reaxy-Rn	1996069

基本描述

1. Rhett JM et al.. (2016) Connexin-Based Therapeutics and Tissue Engineering Approaches to the Amelioration of Chronic Pancreatitis and Type I Diabetes: Construction and Characterization of a Novel Prevascularized Bioartificial Pancreas.. J Diabetes Res, 2016 (): (7262680). [PMID:26788521]
2. Sui S et al.. (2021) iPSC-Derived Trabecular Meshwork Cells Stimulate Endogenous TM Cell Division Through Gap Junction in a Mouse Model of Glaucoma.. Invest Ophthalmol Vis Sci, 62 (10): (28). [PMID:34427623]