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抑胃肽

有效的促胰岛素性肠激素；GIP激动剂
规格或纯度: ≥95% (HPLC)
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货号 (SKU) 包装规格 是否现货 价格 数量
G118955-0.5mg
 0.5mg 现货 Stock Image
G118955-1mg
 1mg 现货 Stock Image
G118955-2.5mg
 2.5mg 现货 Stock Image
G118955-10mg
 10mg 现货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
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GIP receptor Agonist
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基本描述

别名 GIP
英文别名 Glucose-dependent Insulinotropic Peptide
规格或纯度 ≥95% (HPLC)
英文名称 Gastric Inhibitory Polypeptide human
生化机理 由十二指肠K细胞合成的强促胰岛素激素。高亲和力GIP受体激动剂（EC50 = 0.81 nM），可抑制胃酸分泌并刺激葡萄糖响应胰腺的胰岛素释放。还影响脂质代谢，并在胰腺β细胞中显示有丝分裂和抗凋亡作用。
储存温度 -20°C储存
运输条件 超低温冰袋运输
产品介绍

Amino Acid Sequence Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-GlnwGastric Inhibitory Peptide (GIP), human 是一种是胃功能抑制剂。

Amino Acid Sequence Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Glnw
Gastric Inhibitory Peptide (GIP), human is thought to act as an inhibitor of gastric functions.

名称和标识符

IUPAC Name 5-amino-2-[[2-[[2-[[4-amino-2-[[2-[[6-amino-2-[[2-[[2-[[4-amino-2-[[6-amino-2-[[6-amino-2-[[2-[[6-amino-2-[[5-amino-2-[2-[[2-[[2-[[2-[[4-amino-2-[[2-[[2-[[2-[[5-amino-2-[[5-amino-2-[[2-[[2-[[6-amino-2-[[2-[[2-[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]-4-carboxybutanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]propanoylamino]-4-methylsulfanylbutanoyl]amino]-3-carboxypropanoyl]amino]hexanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-carboxypropanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]propanoylamino]-5-oxopentanoyl]amino]hexanoyl]amino]acetyl]amino]hexanoyl]amino]hexanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-oxobutanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-5-oxopentanoic acid
INCHI InChI=1S/C226H338N60O66S/c1-21-113(11)181(285-218(343)165(107-288)278-203(328)150(88-125-60-64-131(292)65-61-125)264-212(337)163(99-179(310)311)274-217(342)164(106-287)279-222(347)183(115(13)23-3)283-215(340)152(87-123-47-29-26-30-48-123)275-224(349)185(120(18)289)280-174(301)105-245-192(317)142(70-75-175(302)303)252-187(312)117(15)248-190(315)134(232)85-124-58-62-130(291)63-59-124)220(345)250-119(17)189(314)254-146(76-82-353-20)199(324)272-160(96-176(304)305)210(335)258-141(57-39-44-81-231)200(325)282-182(114(12)22-2)221(346)276-156(92-129-103-241-109-247-129)206(331)260-144(67-72-167(234)294)197(322)259-145(68-73-168(235)295)198(323)271-161(97-177(306)307)211(336)265-151(86-122-45-27-25-28-46-122)214(339)281-180(112(9)10)219(344)277-158(94-171(238)298)209(334)266-154(90-127-101-243-136-52-34-32-50-133(127)136)205(330)263-149(84-111(7)8)202(327)262-148(83-110(5)6)201(326)249-118(16)188(313)253-143(66-71-166(233)293)196(321)255-137(53-35-40-77-227)191(316)244-104-173(300)251-138(54-36-41-78-228)193(318)256-139(55-37-42-79-229)195(320)269-157(93-170(237)297)208(333)273-162(98-178(308)309)213(338)267-153(89-126-100-242-135-51-33-31-49-132(126)135)204(329)257-140(56-38-43-80-230)194(319)268-155(91-128-102-240-108-246-128)207(332)270-159(95-172(239)299)216(341)284-184(116(14)24-4)223(348)286-186(121(19)290)225(350)261-147(226(351)352)69-74-169(236)296/h25-34,45-52,58-65,100-103,108-121,134,137-165,180-186,242-243,287-292H,21-24,35-44,53-57,66-99,104-107,227-232H2,1-20H3,(H2,233,293)(H2,234,294)(H2,235,295)(H2,236,296)(H2,237,297)(H2,238,298)(H2,239,299)(H,240,246)(H,241,247)(H,244,316)(H,245,317)(H,248,315)(H,249,326)(H,250,345)(H,251,300)(H,252,312)(H,253,313)(H,254,314)(H,255,321)(H,256,318)(H,257,329)(H,258,335)(H,259,322)(H,260,331)(H,261,350)(H,262,327)(H,263,330)(H,264,337)(H,265,336)(H,266,334)(H,267,338)(H,268,319)(H,269,320)(H,270,332)(H,271,323)(H,272,324)(H,273,333)(H,274,342)(H,275,349)(H,276,346)(H,277,344)(H,278,328)(H,279,347)(H,280,301)(H,281,339)(H,282,325)(H,283,340)(H,284,341)(H,285,343)(H,286,348)(H,302,303)(H,304,305)(H,306,307)(H,308,309)(H,310,311)(H,351,352)
InChi Key MGXWVYUBJRZYPE-UHFFFAOYSA-N
Canonical SMILES CCC(C)C(C(=O)NC(CC1=CNC=N1)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(C(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(CCC(=O)N)C(=O)NC(CCCCN)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(CC5=CNC6=CC=CC=C65)C(=O)NC(CCCCN)C(=O)NC(CC7=CNC=N7)C(=O)NC(CC(=O)N)C(=O)NC(C(C)CC)C(=O)NC(C(C)O)C(=O)NC(CCC(=O)N)C(=O)O)NC(=O)C(CCCCN)NC(=O)C(CC(=O)O)NC(=O)C(CCSC)NC(=O)C(C)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(CC8=CC=C(C=C8)O)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)CC)NC(=O)C(CC9=CC=CC=C9)NC(=O)C(C(C)O)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CC1=CC=C(C=C1)O)N
PubChem CID 131954558
分子量 4983.53

化学和物理性质

溶解性 Soluble to 1 (mg/mL) in water}

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参考文献

1. A J Moody,L Thim,I Valverde.  (1984-07-09)  The isolation and sequencing of human gastric inhibitory peptide (GIP)..  FEBS letters,  172  ((2)):  (142-148).  [PMID:6745415]
2. Valeriya Lyssenko,Lena Eliasson,Olga Kotova,Kasper Pilgaard,Nils Wierup,Albert Salehi,Anna Wendt,Anna Jonsson,Yang Z De Marinis,Lisa M Berglund,Jalal Taneera,Alexander Balhuizen,Ola Hansson,Peter Osmark,Pontus Dunér,Charlotte Brøns,Alena Stancáková,Johanna Kuusisto,Marco Bugliani,Richa Saxena,Emma Ahlqvist,Timothy J Kieffer,Tiinamaija Tuomi,Bo Isomaa,Olle Melander,Emily Sonestedt,Marju Orho-Melander,Peter Nilsson,Sara Bonetti,Riccardo Bonadonna,Roberto Miccoli,Stefano Delprato,Piero Marchetti,Sten Madsbad,Pernille Poulsen,Allan Vaag,Markku Laakso,Maria F Gomez,Leif Groop.  (2011-08-04)  Pleiotropic effects of GIP on islet function involve osteopontin..  Diabetes,  60  ((9)):  (2424-2433).  [PMID:21810601]
3. Nigel Irwin,Jacqueline M E Francis,Peter R Flatt.  (2011-08-20)  Insulin modulates glucose-dependent insulinotropic polypeptide (GIP) secretion from enteroendocrine K cells in rats..  Biological chemistry,  392  ((10)):  (909-918).  [PMID:21851286]
4. Priya Sumithran,Luke A Prendergast,Elizabeth Delbridge,Katrina Purcell,Arthur Shulkes,Adamandia Kriketos,Joseph Proietto.  (2011-10-28)  Long-term persistence of hormonal adaptations to weight loss..  The New England journal of medicine,  365  ((17)):  (1597-1604).  [PMID:22029981]
5. Jennifer D Könitzer,Shreya Pramanick,Qi Pan,Robert Augustin,Sebastian Bandholtz,William Harriman,Shelley Izquierdo.  (2017-01-06)  Generation of a highly diverse panel of antagonistic chicken monoclonal antibodies against the GIP receptor..  mAbs,  9  ((3)):  (536-549).  [PMID:28055305]
6. H Yajima,N Fujii,K Akaji,M Sakurai,M Nomizu,K Mizuta,M Aono,M Moriga,K Inoue,R Hosotani.  (1985-08-01)  Synthesis of a 42 residue peptide corresponding to the entire amino acid sequence of human GIP..  Chemical & pharmaceutical bulletin,  33  ((8)):  (3578-3581).  [PMID:3910280]
7. Sabrina Paratore,Maria Teresa Ciotti,Magali Basille,David Vaudry,Antonietta Gentile,Rosalba Parenti,Pietro Calissano,Sebastiano Cavallaro.  (2011-09-17)  Gastric inhibitory polypeptide and its receptor are expressed in the central nervous system and support neuronal survival..  Central nervous system agents in medicinal chemistry,  11  ((3)):  (210-222).  [PMID:21919873]

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