Infliximab (anti-TNF-alpha)

功能和特点

规格或纯度: Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
应用: ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
反应种属: Cynomolgus,Human
亚型: Human IgG1

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货号 (SKU)	包装规格	是否现货
I412009-1mg (试用装) 申请此免费试用装（?）作为尊贵的客户，您每年可免费申请一次试用装产品，尽享探索与享受！	1mg	现货
I412009-5mg	5mg	现货
I412009-10mg	10mg	期货

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基本信息

产品名称	Infliximab (anti-TNF-alpha)
别名	Infliximab; Remicade; Remsima; Inflectra; Avakine; CT-P13; 英夫利昔单抗; APC1 antibody; APC1 protein antibody; Cachectin antibody; DIF antibody; Differentiation inducing factor antibody; Macrophage cytotoxic factor antibody; Tnf antibody; TNF superfamily member
英文别名	Infliximab; Remicade; Remsima; Inflectra; Avakine; CT-P13; APC1 antibody; APC1 protein antibody; Cachectin antibody; DIF antibody; Differentiation inducing factor antibody; Macrophage cytotoxic factor antibody; Tnf antibody; TNF superfamily member 2 antib
规格或纯度	Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
特异性	TNFSF2/TNFa
应用	ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
反应种属	Cynomolgus,Human

产品属性

抗体类型	Primary antibody
Format	Whole IgG
亚型	Human IgG1
轻链亚型	Kappa
SDS-PAGE	27.6 kDa (Light Chain) & 52.7 kDa (Heavy Chain), under reducing conditions; 186.7 kDa, under non-reducing conditions.
纯化方法	Protein A purified
来源	CHO supernatant
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-AC, 20mM Arg, pH 5.0
防腐剂	No
浓度	Lot by Lot
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at -80℃ for 18 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS编号和信息	170277-31-3

数据库链接

Wikipedia	Infliximab
IMGT/mAb-DB	156
PubChem SID	178101701
PEP	infliximab
Immunopaedia Search	infliximab

图片

ELISA: Infliximab (anti-TNF-alpha) (I412009)

Infliximab (anti-TNF-alpha) (I412009) - ELISA
Immobilized Recombinant Human TNF-alpha Protein (rp156007) at 0.5 μg/mL can bind Infliximab (anti-TNF-alpha) (I412009) with the EC₅₀ of 31.52 ng/mL.

SEC: Infliximab (anti-TNF-alpha) (I412009)

Infliximab (anti-TNF-alpha) (I412009) - SEC
The purity of Infliximab (anti-TNF-alpha) (I412009) is more than 95% verified by HPLC.

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您好，Infliximab (anti-TNF-alpha)，货号I412009-1mg，网站页说到，储存缓冲液为Supplied as a 0.22 μm filtered solution in 100mM Pro-AC, 20mM Arg, pH 5.0。请问100mM Pro-AC是什么物质，Pro-AC是protein A和protein C吗？

问题由韦晓云于 2023年10月26日上午11:09 创建

您好，该产品的储存缓冲液Pro-AC是指脯氨酸醋酸缓冲液。

参考文献

1. Rutgeerts P, D'Haens G, Targan S, Vasiliauskas E, Hanauer SB, Present DH, Mayer L, Van Hogezand RA, Braakman T, DeWoody KL et al.. (1999) Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease.. Gastroenterology, 117 (4): (761-9). [PMID:10500056]
2. Blair HA, Deeks ED. (2016) Infliximab Biosimilar (CT-P13; Infliximab-dyyb): A Review in Autoimmune Inflammatory Diseases.. BioDrugs, 30 (5): (469-480). [PMID:27650650]
3. Yoo DH, Prodanovic N, Jaworski J, Miranda P, Ramiterre E, Lanzon A, Baranauskaite A, Wiland P, Abud-Mendoza C, Oparanov B et al.. (2017) Efficacy and safety of CT-P13 (biosimilar infliximab) in patients with rheumatoid arthritis: comparison between switching from reference infliximab to CT-P13 and continuing CT-P13 in the PLANETRA extension study.. Ann Rheum Dis, 76 (2): (355-363). [PMID:27130908]
4. Derzi M, Johnson TR, Shoieb AM, Conlon HD, Sharpe P, Saati A, Koob S, Bolt MW, Lorello LG, McNally J et al.. (2016) Nonclinical Evaluation of PF-06438179: A Potential Biosimilar to Remicade(®) (Infliximab).. Adv Ther, 33 (11): (1964-1982). [PMID:27585978]
5. van Dullemen HM, van Deventer SJ, Hommes DW, Bijl HA, Jansen J, Tytgat GN, Woody J. (1995) Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2).. Gastroenterology, 109 (1): (129-35). [PMID:7797011]
6. A-González N, Castrillo A. (2011) Liver X receptors as regulators of macrophage inflammatory and metabolic pathways.. Biochim Biophys Acta, 1812 (8): (982-94). [PMID:21193033]

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Infliximab (anti-TNF-alpha)

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基本信息

产品属性

数据库链接

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质检报告(COA)

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相关文档

产品问答

产品问答

参考文献

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