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货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
---|---|---|---|---|
L129320-10mg |
10mg |
现货 ![]() |
| |
L129320-50mg |
50mg |
现货 ![]() |
| |
L129320-100mg |
100mg |
现货 ![]() |
| |
L129320-250mg |
250mg |
现货 ![]() |
| |
L129320-1g |
1g |
现货 ![]() |
|
别名 | ABT-378;洛匹那韦 |
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英文别名 | ABT-378;Aluviran; Koletra; ABT 378; ABT378;(2S)-N-[(2R,4S,5S)-5-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenyl-hexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide;(aS)-N-[(1S,3S,4S)-4-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy- |
规格或纯度 | ≥99% |
英文名称 | Lopinavir |
生化机理 | Lopinavir is an antiretroviral of the protease inhibitor class. Inhibition of HIV-1 protease prevents cleavage of the viral polyprotein precursor and results in the release of immature, noninfectious virions. A component of combination therapy to treat HIV/AIDS. |
应用 | Lopinavir has been used as a ZMPSTE24 and human immunodeficiency virus protease inhibitor. |
储存温度 | -20°C储存 |
运输条件 | 超低温冰袋运输 |
产品介绍 |
Lopinavir is an antiviral HIV Protease Inhibitor. Lopinavir has insufficient bioavailability alone, so it is used in therapy in combination with Ritonavir, a HIV protease inhibitor, which inhibits cytochrome P450-3A4 (CYP3A4), a liver enzyme that normally metabolizes protease inhibitors. Lopinavir also has an ability to inhibit ZMPSTE24 (zinc metallopeptidase STE24).Lopinavir has been used as a ZMPSTE24 and human immunodeficiency virus protease inhibitor. Lopinavir is an antiviral HIV Protease Inhibitor. Lopinavir has insufficient bioavailability alone, so it is used in therapy in combination with Ritonavir, a HIV protease inhibitor, which inhibits cytochrome P450-3A4 (CYP3A4), a liver enzyme that normally metabolizes protease inhibitors. Lopinavir also has an ability to inhibit ZMPSTE24 (zinc metallopeptidase STE24). |
IUPAC Name | (2S)-N-[(2S,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide |
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INCHI | InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1 |
InChi Key | KJHKTHWMRKYKJE-SUGCFTRWSA-N |
Canonical SMILES | CC1=C(C(=CC=C1)C)OCC(=O)NC(CC2=CC=CC=C2)C(CC(CC3=CC=CC=C3)NC(=O)C(C(C)C)N4CCCNC4=O)O |
PubChem CID | 92727 |
分子量 | 628.8 |
溶解性 | Soluble in DMF (~14 mg/ml), methanol, DMSO (126 mg/ml at 25 °C), water (< 1 mg/ml at 25 °C), and ethanol (126 mg/ml at 25 °C). |
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熔点 | 124-127°C |
象形图 |
![]() Health Hazard ![]() Harmful |
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信号词 | Warning |
危险声明 |
H315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation H373: Causes damage to organs through prolonged or repeated exposure |
预防措施声明 | P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319 |
输入批号以搜索COA:
1. Sham HL, Betebenner DA, Herrin T, Kumar G, Saldivar A, Vasavanonda S, Molla A, Kempf DJ, Plattner JJ, Norbeck DW. (2001) Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir).. Bioorg Med Chem Lett, 11 (11): (1351-3). [PMID:11378352] |
2. de Wilde AH, Jochmans D, Posthuma CC, Zevenhoven-Dobbe JC, van Nieuwkoop S, Bestebroer TM, van den Hoogen BG, Neyts J, Snijder EJ. (2014) Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture.. Antimicrob Agents Chemother, 58 (8): (4875-84). [PMID:24841269] |
3. Böhm R, Bulin C, Waetzig V, Cascorbi I, Klein HJ, Herdegen T. (2021) Pharmacovigilance-based drug repurposing: The search for inverse signals via OpenVigil identifies putative drugs against viral respiratory infections.. Br J Clin Pharmacol, 71 (13): (1755-70). [PMID:33871897] |
4. Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, Ruan L, Song B, Cai Y, Wei M et al.. (2020) A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19.. N Engl J Med, 382 (19): (1787-1799). [PMID:32187464] |