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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| N172464-100mg |
100mg |
期货  |
|
| 规格或纯度 | 97% |
|---|---|
| 英文名称 | NITD-609 |
| 储存温度 | 室温 |
| 运输条件 | 常规运输 |
| IUPAC Name | (3R,3'S)-5,7'-dichloro-6'-fluoro-3'-methylspiro[1H-indole-3,1'-2,3,4,9-tetrahydropyrido[3,4-b]indole]-2-one |
|---|---|
| INCHI | InChI=1S/C19H14Cl2FN3O/c1-8-4-11-10-6-14(22)13(21)7-16(10)23-17(11)19(25-8)12-5-9(20)2-3-15(12)24-18(19)26/h2-3,5-8,23,25H,4H2,1H3,(H,24,26)/t8-,19+/m0/s1 |
| InChi Key | CKLPLPZSUQEDRT-WPCRTTGESA-N |
| Canonical SMILES | CC1CC2=C(C3(N1)C4=C(C=CC(=C4)Cl)NC3=O)NC5=CC(=C(C=C25)F)Cl |
| PubChem CID | 44469321 |
| 分子量 | 390.24 |
| PubChem CID | 44469321 |
|---|---|
| Wikipedia | Cipargamin |
| ChEMBL Ligand | CHEMBL1082723 |
| CAS Registry No. | 1193314-23-6 |
输入批号以搜索COA:
| 1. Yeung BK, Zou B, Rottmann M, Lakshminarayana SB, Ang SH, Leong SY, Tan J, Wong J, Keller-Maerki S, Fischli C et al.. (2010) Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.. J Med Chem, 53 (14): (5155-64). [PMID:20568778] |
| 2. Rottmann M, McNamara C, Yeung BK, Lee MC, Zou B, Russell B, Seitz P, Plouffe DM, Dharia NV, Tan J et al.. (2010) Spiroindolones, a potent compound class for the treatment of malaria.. Science, 329 (5996): (1175-80). [PMID:20813948] |
| 3. van Pelt-Koops JC, Pett HE, Graumans W, van der Vegte-Bolmer M, van Gemert GJ, Rottmann M, Yeung BK, Diagana TT, Sauerwein RW. (2012) The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to anopheles mosquito vector.. Antimicrob Agents Chemother, 56 (7): (3544-8). [PMID:22508309] |
| 4. Spillman NJ, Allen RJ, McNamara CW, Yeung BK, Winzeler EA, Diagana TT, Kirk K. (2013) Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials.. Cell Host Microbe, 13 (2): (227-37). [PMID:23414762] |
| 5. White NJ, Pukrittayakamee S, Phyo AP, Rueangweerayut R, Nosten F, Jittamala P, Jeeyapant A, Jain JP, Lefèvre G, Li R et al.. (2014) Spiroindolone KAE609 for falciparum and vivax malaria.. N Engl J Med, 371 (5): (403-10). [PMID:25075833] |
| 6. Stein DS, Jain JP, Kangas M, Lefèvre G, Machineni S, Griffin P, Lickliter J. (2015) Open-label, single-dose, parallel-group study in healthy volunteers to determine the drug-drug interaction potential between KAE609 (cipargamin) and piperaquine.. Antimicrob Agents Chemother, 59 (6): (3493-500). [PMID:25845867] |
| 7. Goldgof GM, Durrant JD, Ottilie S, Vigil E, Allen KE, Gunawan F, Kostylev M, Henderson KA, Yang J, Schenken J et al.. (2016) Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor.. Sci Rep, 6 (13): (27806). [PMID:27291296] |
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