Pembrolizumab (anti-PD-1)

规格或纯度: Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

CAS编号: 1374853-91-4
EC号: 807-012-2
PubChem编号: 168009853
基因ID: 5133
蛋白质编号: Q15116

有货

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库存信息

关闭

货号 (SKU)	包装规格	是否现货
P411997-1mg	1mg	现货
P411997-5mg	5mg	现货
P411997-10mg	10mg	期货

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programmed cell death 1 (CD279) Antibody

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基本描述

别名	派姆单抗; 帕博利珠单抗; Recombinant Pembrolizumab Antibody; Pembrolizumab (anti-PD-1); Pembrolizumab; MK-3475; Lambrolizumab; CD279 antibody; CD279 antigen antibody; hPD 1 antibody; hPD l antibody; hPD-1 antibody; hSLE1 antibody; PD 1 antibody; PD-1 antibody; PD1 a
英文别名	Recombinant Pembrolizumab Antibody; Pembrolizumab (anti-PD-1); Pembrolizumab; MK-3475; Lambrolizumab; CD279 antibody; CD279 antigen antibody; hPD 1 antibody; hPD l antibody; hPD-1 antibody; hSLE1 antibody; PD 1 antibody; PD-1 antibody; PD1 antibody; PDCD
规格或纯度	Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
英文名称	Pembrolizumab (anti-PD-1)
稳定性与储存	Store at -80℃ for 18 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
应用	ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
来源	CHO supernatant
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
产品介绍	Pembrolizumab 是一种有效的、高选择性的、人源IgG4-kappa单克隆抗体，同时也是抑制剂，靶向PD-1，具有潜在的免疫检查点抑制活性和抗肿瘤活性。 Pembrolizumab (anti-PD-1) is a potent, highly selective, fully humanized immunoglobulin (Ig) G4-kappa monoclonal antibody against PD-1 with potential immune checkpoint inhibitory and antineoplastic activities. Purity >95% (SDS-PAGE&SEC) Endotoxin Level < 1.0EU/mg

名称和标识符

EC号	807-012-2
IUPAC Name	1-butyl-4-propylpiperazine;ethane;1-[hex-5-enyl(2-methyltetradecyl)amino]tetradecan-2-ol;3-[2-methylhexadeca-8,10-dienyl(2-methylhexadeca-9,11-dienyl)amino]propane-1-thiol
INCHI	InChI=1S/C37H69NS.C35H71NO.C11H24N2.C2H6/c1-5-7-9-11-13-15-17-19-21-23-25-27-30-36(3)34-38(32-29-33-39)35-37(4)31-28-26-24-22-20-18-16-14-12-10-8-6-2;1-5-8-11-14-16-18-20-22-24-26-29-34(4)32-36(31-28-13-10-7-3)33-35(37)30-27-25-23-21-19-17-15-12-9-6-2;1-3-5-7-13-10-8-12(6-4-2)9-11-13;1-2/h11,13-18,20,36-37,39H,5-10,12,19,21-35H2,1-4H3;7,34-35,37H,3,5-6,8-33H2,1-2,4H3;3-11H2,1-2H3;1-2H3
InChi Key	AMOIBCKFWIUEKF-UHFFFAOYSA-N
Canonical SMILES	CC.CCCCCCCCCCCCC(C)CN(CCCCC=C)CC(CCCCCCCCCCCC)O.CCCCCC=CC=CCCCCCC(C)CN(CCCS)CC(C)CCCCCCC=CC=CCCCC.CCCCN1CCN(CC1)CCC
关联CAS	1374853-91-4
PubChem CID	168009853

数据库链接

IMGT/mAb-DB	472
Wikipedia	Pembrolizumab
PubChem SID	187051801

图片

Flow Cytometry: Pembrolizumab (anti-PD-1) (P411997)

Pembrolizumab (anti-PD-1) (P411997) - Flow Cytometry
Flow Cytometry analysis of PHA-stimulated (3 days) human peripheral blood mononuclear lymphocytes labelling PD-1 (red) with Pembrolizumab (anti-PD-1) (P411997). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Pembrolizumab (anti-PD-1) (P411997)

Pembrolizumab (anti-PD-1) (P411997) - SEC
The purity of Pembrolizumab (anti-PD-1) (P411997) is more than 95% verified by HPLC.

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参考文献

1. Janakiram M, Abadi YM, Sparano JA, Zang X. (2012) T cell coinhibition and immunotherapy in human breast cancer.. Discov Med, 14 (77): (229-36). [PMID:23114578]
2. Greaves P, Gribben JG. (2013) The role of B7 family molecules in hematologic malignancy.. Blood, 121 (5): (734-44). [PMID:23223433]
3. Tang PA, Heng DY. (2013) Programmed death 1 pathway inhibition in metastatic renal cell cancer and prostate cancer.. Curr Oncol Rep, 15 (2): (98-104). [PMID:23263823]
4. Hamid O, Robert C, Daud A, Hodi FS, Hwu WJ, Kefford R, Wolchok JD, Hersey P, Joseph RW, Weber JS et al.. (2013) Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma.. N Engl J Med, 369 (2): (134-44). [PMID:23724846]
5. Nghiem PT, Bhatia S, Lipson EJ, Kudchadkar RR, Miller NJ, Annamalai L, Berry S, Chartash EK, Daud A, Fling SP et al.. (2016) PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma.. N Engl J Med, 374 (26): (2542-52). [PMID:27093365]
6. Paz-Ares L, Luft A, Vicente D, Tafreshi A, Gümüş M, Mazières J, Hermes B, Çay Şenler F, Csőszi T, Fülöp A et al.. (2018) Pembrolizumab plus Chemotherapy for Squamous Non-Small-Cell Lung Cancer.. N Engl J Med, 379 (21): (2040-2051). [PMID:30280635]
7. Rini BI, Plimack ER, Stus V, Gafanov R, Hawkins R, Nosov D, Pouliot F, Alekseev B, Soulières D, Melichar B et al.. (2019) Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma.. N Engl J Med, 380 (12): (1116-1127). [PMID:30779529]
8. Saada-Bouzid E, Peyrade F, Guigay J. (2019) Immunotherapy in recurrent and or metastatic squamous cell carcinoma of the head and neck.. Curr Opin Oncol, 31 (3): (146-151). [PMID:30893146]

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Pembrolizumab (anti-PD-1)

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