Recombinant Human CCL8/MCP-2 Protein

功能和特点

规格或纯度: Animal Free, >96%( SDS-PAGE and HPLC), Active, E.coli, No tag, 24-99 aa
生物活性: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 10-100 ng/ml.
蛋白标签: No tag
应用: Cell Culture,SDS-PAGE,Active standard

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货号 (SKU)	包装规格	是否现货
rp148607-10μg (试用装) 申请此免费试用装（?）作为尊贵的客户，您每年可免费申请一次试用装产品，尽享探索与享受！	10μg	现货
rp148607-50μg	50μg	现货
rp148607-100μg	100μg	现货
rp148607-1mg	1mg	期货

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基本描述

产品名称	Recombinant Human CCL8/MCP-2 Protein
别名	重组人 CCL8/MCP-2 蛋白;C-C motif chemokine 8; CCL8; Chemokine (C-C motif) ligand 8; HC14; MCP2; MCP-2; Member 8 (monocyte chemotactic protein 2); Monocyte chemoattractant protein 2; SCYA10; Small-inducible cytokine A8
英文别名	C-C motif chemokine 8; CCL8; Chemokine (C-C motif) ligand 8; HC14; MCP2; MCP-2; Member 8 (monocyte chemotactic protein 2); Monocyte chemoattractant protein 2; SCYA10; Small-inducible cytokine A8
规格或纯度	Animal Free, >96%( SDS-PAGE and HPLC), Active, E.coli, No tag, 24-99 aa
产品介绍	Purity Human CCL8, also known as monocyte chemotactic protein 2 (MCP-2), is belonging to the CC chemokine family. It is encoded by the gene CCL8. MCP-2 has two homogeneous MCP-1 (CCL2) and MCP-3 (CCL7). These three MCPs were found by IL-1-beta triggered human MG-63 osteosarcoma cells. CCL8 shares 62 % amino acid sequence identity with MCP-1, and shares 58 % amino acid sequence identity with MCP-2. CCL8 has chemotactic function for monocytes, eosinophils and neutrophils. In addition, it can also chemoattract activated NK cells. Purity >96% by SDS-PAGE and HPLC analyses. Additional sequence information Full-length mature C-C motif chemokine 8 chain lacking the signal peptide. Function Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. Post-translational N-terminal processed form MCP-2(6-76) is produced by proteolytic cleavage after secretion from peripheral blood monocytes. MCP-2 and MCP-3 are two monocyte chemotactic proteins produced by human MG-63 osteosarcoma cells. Both MCP-2 and MCP-3 are members of the C-C family of chemokines and share 62% and 71% amino acid sequence identity, respectively, with MCP-1. MCP-3 also shares 58% amino acid identity with MCP-2. Similarly to other C-C chemokines, all three MCP proteins are monocyte chemoattractants. In addition, the three MCPs can chemoattract activated NK cells as well as CD4+ and CD8+ T lymphocytes. All three cytokines have also been shown to attract eosinophils and induce histamine secretion from basophils.
生物活性	Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 10-100 ng/ml.
纯度	＞96%( SDS-PAGE and HPLC)
内毒素水平	< 1 EU/μg
表达系统	E.coli
种属	Human
氨基酸	24-99 aa
序列	QPDSVSIPIT CCFNVINRKI PIQRLESYTR ITNIQCPKEA VIFKTKRGKE VCADPKERWV RDSMKHLDQI FQNLKP
蛋白标签	No tag
无动物源	Yes
Accession #	P80075
来源	Recombinant
预测分子量	8.9 kDa
SDS-PAGE	8.9 kDa

产品规格参数

应用	Cell Culture,SDS-PAGE,Active standard
物理外观	Lyophilized
储存缓冲液	Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, pH 7.4, 100 mM NaCl.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportio
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Upon delivery aliquot, Store at -20°C, Avoid freeze / thaw cycles. Lyophilized with no additives. This product is an active protein and may elicit a biological response in vivo, handle with caution.

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Protein Bioactivity: Recombinant Human CCL8/MCP-2 Protein (rp148607)

Recombinant Human CCL8/MCP-2 Protein (rp148607)-Protein Bioactivity
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 10-100 ng/mL.

SDS-PAGE: Recombinant Human CCL8/MCP-2 Protein (rp148607)

Recombinant Human CCL8/MCP-2 Protein (rp148607)-SDS-PAGE
Recombinant Human CCL8/MCP-2 Protein was resolved with SDS-PAGE under reducing (R) and visualized by Coomassie® Blue staining, Showing a single band at 7.8 kDa.

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Recombinant Human CCL8/MCP-2 Protein

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