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Recombinant Human Osteoprotegerin Protein

Recombinant Human Osteoprotegerin Protein

功能和特点

规格或纯度: Animal Free, >95%(SDS-PAGE, HPLC), Active, E.coli, No tag, 22-194 aa
生物活性: Fully biologically active when compared to standard. The ED50 as determined by neutralizing the stimulation of U937 cells is less than 10 ng/ml in the presence of 10 ng/mL soluble rHuRANKL (sRANKL).
蛋白标签: No tag
应用: Active, SDS-PAGE

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货号 (SKU)	包装规格	是否现货
rp149600-10μg (试用装) 申请此免费试用装（?）作为尊贵的客户，您每年可免费申请一次试用装产品，尽享探索与享受！	10μg	现货
rp149600-50μg	50μg	现货
rp149600-100μg	100μg	现货
rp149600-1mg	1mg	期货

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基本描述

产品名称	Recombinant Human Osteoprotegerin Protein
别名	OCIF; OCIFMGC29565; OPG; OPGtumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin; TNFRSF11B; TR1; tumor necrosis factor receptor superfamily, member 11b; PDB5; 重组人骨保护素蛋白; 重组人TR11B蛋白
英文别名	OCIF; OCIFMGC29565; OPG; OPGtumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin; TNFRSF11B; TR1; tumor necrosis factor receptor superfamily, member 11b; PDB5
规格或纯度	Animal Free, >95%(SDS-PAGE, HPLC), Active, E.coli, No tag, 22-194 aa
产品介绍	Purity > 95 % by SDS-PAGE and HPLC analyses. Function Osteoprotegerin (OPG), also named osteoclastogenesis inhibitory factor (OCIF), and tumor necrosis factor receptor superfamily member 11B (TNFRSF11B), is a TNFRSF11B-encoded protein in humans. Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.OPG has been applied to decrease bone resorption in women with postmenopausal osteoporosis and in patients with lytic bone metastases.
生物活性	Fully biologically active when compared to standard. The ED50 as determined by neutralizing the stimulation of U937 cells is less than 10 ng/ml in the presence of 10 ng/mL soluble rHuRANKL (sRANKL).
纯度	＞95%(SDS-PAGE, HPLC)
内毒素水平	＜1 EU/μg
表达系统	E.coli
种属	Human
氨基酸	22-194 aa
序列	ETFPPKYLHY DEETSHQLLC DKCPPGTYLK QHCTAKWKTV CAPCPDHYYT DSWHTSDECL YCSPVCKELQ YVKQECNRTH NRVCECKEGR YLEIEFCLKH RSCPPGFGVV QAGTPERNTV CKRCPDGFFS NETSSKAPCR KHTNCSVFGL LLTQKGNATH DNICSGNSES TQK
蛋白标签	No tag
蛋白长度	Protein fragment
无动物源	Yes
Accession #	O00300
来源	Recombinant
预测分子量	19.7 kDa

产品规格参数

应用	Active, SDS-PAGE
物理外观	Lyophilized
储存缓冲液	Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB,150 mM NaCl, pH 6.0
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportio
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ℃ as supplied; 1 month, 2 to 8 ℃ under sterile conditions after reconstitution; 3 months, -20 to -70 ℃under sterile conditions after reconstitut

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Protein Bioactivity: Recombinant Human Osteoprotegerin Protein (rp149600)

Recombinant Human Osteoprotegerin Protein (rp149600)-Protein Bioactivity
Fully biologically active when compared to standard. The ED₅₀ as determined by neutralizing the stimulation of U937 cells is less than 10 ng/mL, corresponding to a specific activity of > 1.0 ×10⁵ IU/mg in the presence of 10 ng/mL soluble rHuRANKL (sRANKL).

SDS-PAGE: Recombinant Human Osteoprotegerin Protein (rp149600)

Recombinant Human Osteoprotegerin Protein (rp149600)-SDS-PAGE
Recombinant Human Osteoprotegerin Protein was resolved with SDS-PAGE under reducing (R) and visualized by Coomassie® Blue staining, showing a single band at 20.7 kDa.

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Recombinant Human Osteoprotegerin Protein

库存信息

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库存信息

基本描述

产品规格参数

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