Recombinant Human HMGB1 Protein

功能和特点

规格或纯度: Carrier free, >90% (SDS-PAGE), E.coli, N-His tag, 1-215 aa
蛋白标签: N-His tag

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货号 (SKU)	包装规格	是否现货
rp156653-10μg (试用装) 申请此免费试用装（?）作为尊贵的客户，您每年可免费申请一次试用装产品，尽享探索与享受！	10μg	现货
rp156653-50μg	50μg	现货
rp156653-100μg	100μg	现货
rp156653-1mg	1mg	期货

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基本描述

产品名称	Recombinant Human HMGB1 Protein
别名	Amphoterin; Chromosomal protein; nonhistone; HMG1; DKFZp686A04236; High mobility group 1; High mobility group box 1; High mobility group protein 1; High mobility group protein B1; high-mobility group (nonhistone chromosomal) protein 1; HMG-1; HMG1; HMG3;
英文别名	Amphoterin; Chromosomal protein; nonhistone; HMG1; DKFZp686A04236; High mobility group 1; High mobility group box 1; High mobility group protein 1; High mobility group protein B1; high-mobility group (nonhistone chromosomal) protein 1; HMG-1; HMG1; HMG3;
规格或纯度	Carrier free, >90% (SDS-PAGE), E.coli, N-His tag, 1-215 aa
产品介绍	Purity: >90%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description: High-mobility group box 1 protein (HMGB1), also known as HMG-1 or amphoterin previously, is a member of the HMGB family consisting of three members, HMGB1, HMGB2, and HMGB3. HMGB1 is a DNA-binding nuclear protein, released actively following cytokine stimulation as well as passively during cell death. It is the prototypic damage-associated molecular pattern (DAMP) molecule and has been implicated in several inflammatory disorders. HMGB1 signals via the receptor for advanced glycation end-product (RAGE) and members of the toll-like receptor (TLR) family. The most prominent HMGB1 protein and mRNA expression arthritis are present in pannus regions, where synovial tissue invades articular cartilage and bone. HMGB1 promotes the activity of proteolytic enzymes, and osteoclasts need HMGB1 for functional maturation. As a non-histone nuclear protein, HMGB1 has a dual function. Inside the cell, HMGB1 binds DNA, regulating transcription, and determining chromosomal architecture. Outside the cell, HMGB1 can serve as an alarmin to activate the innate system and mediate a wide range of physiological and pathological responses. Extracellular HMGB1 represents an optimal " necrotic marker" selected by the innate immune system to recognize tissue damage and initiate reparative responses. However, extracellular HMGB1 also acts as a potent pro-inflammatory cytokine that contributes to the pathogenesis of diverse inflammatory and infectious disorders. HMGB1 has been successfully therapeutically targeted in multiple preclinical models of infectious and sterile diseases including arthritis. As shown in studies on patients as well as animal models, HMGB1 can play an important role in the pathogenesis of the rheumatic disease, including rheumatoid arthritis, systemic lupus erythematosus, and polymyositis among others. Besides, enhanced postmyocardial infarction remodeling in type 1 diabetes mellitus was partially mediated by HMGB1 activation.
表达系统	E.coli
种属	Human
氨基酸	1-215 aa
序列	MGHHHHHHMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE
蛋白标签	N-His tag
无载体	Yes
Accession #	P09429
预测分子量	25.9 kDa
SDS-PAGE	28.5 kDa

产品规格参数

物理外观	Lyophilized
储存缓冲液	Lyophilized from 10mM PBS, PH7.4
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at -20°C for 1 year, store at 2-8℃ for 1 month. Avoid freeze / thaw cycle.

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SDS-PAGE: Recombinant Human HMGB1 Protein (rp156653)

Recombinant Human HMGB1 Protein (rp156653) - SDS-PAGE
3 μg/lane of Recombinant Human HMGB1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 28.5 kDa.

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Recombinant Human HMGB1 Protein

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基本描述

产品规格参数

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