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Recombinant Human LH alpha/beta Heterodimer Protein

功能和特点
  • 规格或纯度: Carrier Free, >90% (SDS-PAGE), E.coli, N-His tag, 25-116 aa & 21-141 aa
  • 蛋白标签: N-His tag
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库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
rp174456-10μg
 10μg 期货 Stock Image
rp174456-100μg
 100μg 期货 Stock Image
rp174456-1mg
 1mg 期货 Stock Image
rp174456-500μg
 500μg 期货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
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LH receptor Agonist
main product photo

基本描述

产品名称 Recombinant Human LH alpha/beta Heterodimer Protein
别名 LH alpha/beta Heterodimer; LH; Luteinizing Hormone alpha/beta Heterodimer; HCG; LHA; FSHA; GPA1; GPHa; TSHA; GPHA1; CG-ALPHA & CGB4; HH23; LSH-B; LSH-beta; CGA; LHB; 重组人LH蛋白; 重组人黄体激素; 重组人黄体生成素
英文别名 LH alpha/beta Heterodimer; LH; Luteinizing Hormone alpha/beta Heterodimer; HCG; LHA; FSHA; GPA1; GPHa; TSHA; GPHA1; CG-ALPHA & CGB4; HH23; LSH-B; LSH-beta; CGA; LHB
规格或纯度 Carrier Free, >90% (SDS-PAGE), E.coli, N-His tag, 25-116 aa & 21-141 aa
产品介绍


Purity
>90% SDS-PAGE.
Background:
Luteinizing Hormone (LH) is a 42 kDa heterodimer belonging to the glycoprotein hormone family. It is composed of noncovalently linked glycosylated alpha and beta chains. The alpha subunit (CG alpha ) is also a component of Follicle-Stimulating Hormone (FSH), Thyroid-Stimulating Hormone, and Chorionic Gonadotropin. The unique beta subunit confers the protein’s specific biological action and is responsible for the interaction with its receptor. The approximately 20 kDa human CG alpha subunit shares 73% and 72% amino acid (aa) sequence identity with the mouse and rat orthologs, respectively. The approximately 18 kDa human LH beta subunit shares 71% and 72% aa sequence identity with the mouse and rat orthologs, respectively. Multiple isoforms of LH exist due to differences in the post-translational glycosylation, sialylation, and sulphation modifications of its subunits. The composition, longevity, and activity of the different LH isoforms vary throughout a woman’s menstrual cycle and reproductive life cycle. LH is produced and secreted by the anterior pituitary gland. Its secretion is controlled by Gonadotropin-Releasing Hormone from the hypothalamus; however, LH secretion can also be stimulated by estradiol. LH works in concert with FSH to regulate female reproduction; FSH stimulates follicular growth and LH induces ovulation. LH also drives formation of the corpus luteum by promoting progesterone production. Additionally, LH has been suggested to stimulate the adrenal gland in postmenopausal women to induce secretion of sulfated DHEA, a precursor to androgens. In the testis, LH induces Leydig cell production of testosterone. Hypersecretion of LH has been shown to occur in women with polycystic ovary syndrome and is associated with an increased risk of infertility and miscarriage. Additionally, increased serum LH levels are associated with decreased cognition and have been implicated in the development and progression of Alzheimer’s disease. receptor into an A-frame.
表达系统 E.coli
氨基酸 25-116 aa & 21-141 aa
序列 APDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHTACHCSTCYYHKSGGGGSGGGGSGGGGSSREPLRPWCHPINAILAVEKEGCPVCITVNTTICAGYCPTMMRVLQAVLPPLPQVVCTYRDVRFESIRLPGCPRGVDPVVSFPVALSCRCGPCRRSTSDCGGPKDHPLTCDHPQLSGLLFL
蛋白标签 N-His tag
无载体 No
无动物源 No
预测分子量 28 kDa
SDS-PAGE 43 kDa under reducing conditions

产品规格参数

物理外观 Lyophilized
储存缓冲液 Lyophilized from 10mM PBS, 5% Trehalose, 0.01% SKL, pH7.4.
复溶 Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 Store at 2-8℃ for one month. Aliquot and store at -80℃ for 12 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS编号和信息 rp174456

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