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Recombinant Human NCAM-1/CD56 Protein

Recombinant Human NCAM-1/CD56 Protein

功能和特点

规格或纯度: Animal Free, >90% SDS-PAGE, CHO, C-His tag, 20-603 aa
蛋白标签: C-His tag

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货号 (SKU)	包装规格	是否现货
rp175917-10μg	10μg	期货
rp175917-100μg	100μg	期货
rp175917-1mg	1mg	期货

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基本描述

产品名称	Recombinant Human NCAM-1/CD56 Protein
别名	CD56/NCAM-1; CD56 antigen; CD56; MSK39; NCAM1; N-CAM-1; NCAM-1; NCAMantigen recognized by monoclonal 5.1H11; neural cell adhesion molecule 1; neural cell adhesion molecule; NCAM; 重组人CD56蛋白; 重组人NCAM-1蛋白
英文别名	CD56/NCAM-1; CD56 antigen; CD56; MSK39; NCAM1; N-CAM-1; NCAM-1; NCAMantigen recognized by monoclonal 5.1H11; neural cell adhesion molecule 1; neural cell adhesion molecule; NCAM
规格或纯度	Animal Free, >90% SDS-PAGE, CHO, C-His tag, 20-603 aa
产品介绍	Purity:>90%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description: Neural cell adhesion molecule 1 (NCAM-1) is a multifunctional member of the Ig superfamily. It belongs to a family of membrane-bound glycoproteins that are involved in Ca++ independent cell matrix and homophilic or heterophilic cell-cell interactions. NCAM-1 specifically binds to heparan sulfate proteoglycans, the extracellular matrix protein agrin, and several chondroitin sulfate proteoglycans that include neurocan and phosphocan. There are three main forms of human NCAM-1 that arise by alternate splicing. These are designated NCAM-120/NCAM-1 (761 amino acids [aa]), NCAM‑140 (848 aa), and NCAM-180 (1120 aa). NCAM-120 is GPI-linked, while NCAM‑140 and NCAM-180 are type I transmembrane glycoproteins. Additional alternate splicing adds considerable diversity to all three forms, and extracellular proteolytic processing is possible for NCAM-180. NCAM-1 is synthesized as a 761 aa preproprecursor that contains a 19 aa signal sequence, a 722 aa GPI-linked mature region, and a 20 aa C-terminal prosegment. The molecule contains five C-2 type Ig-like domains and two fibronectin type-III domains. Human to mouse, NCAM-1 is 93% aa identical. NCAM-1 appears to be highly sialylated. The polysialyation of NCAM-1 reduces its adhesive property and increases its neurite outgrowth promoting features. NCAM-1 in the adult brain shows a decline of sialylation relative to earlier developmental periods. In regions that retain a high degree of neuronal plasticity, however, the adult brain continues to express polysialylation-NCAM-1, suggesting sialylation of NCAM-1 is involved in regenerative processes and synaptic plasticity.
表达系统	CHO
氨基酸	20-603 aa
序列	LQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTI
蛋白标签	C-His tag
无载体	Yes
无动物源	Yes
预测分子量	65.7 kDa
SDS-PAGE	105.8 kDa, under reducing conditions; 94.9 kDa, under non-reducing conditions.

产品规格参数

物理外观	Lyophilized
储存缓冲液	Lyophilized from 20mM Tris, 500mM NaCl, pH7.4
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at -20°C stable up to 1 year. Avoid freeze/thaw cycle.

图片

SDS-PAGE: Recombinant Human NCAM-1/CD56 Protein (rp175917)

Recombinant Human NCAM-1/CD56 Protein (rp175917) - SDS-PAGE
Recombinant Human NCAM-1/CD56 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 105.8 kDa under reducing conditions, showing a band at 94.9 kDa under non-reducing conditions.

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Recombinant Human NCAM-1/CD56 Protein

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基本描述

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